CXCL12/CXCR4 在口腔癌前病变和恶性病变中的表达。
Expressions of CXCL12/CXCR4 in oral premalignant and malignant lesions.
机构信息
Department of Oral Medicine, Guanghua School of Stomatology and Institute of Stomatological Research, Sun Yat-Sen University, Guangdong, Guangzhou, China.
出版信息
Mediators Inflamm. 2012;2012:516395. doi: 10.1155/2012/516395. Epub 2012 Jan 29.
OBJECTIVE
The chemokine receptor CXCR4 and its ligand CXCL12 have been suggested to play important roles in the initiation or progression of cancers. The goal of the present study was to investigate alterations of CXCL12/CXCR4 in oral premalignant lesions and oral squamous cell carcinoma (OSCC).
METHODS
In 13 normal oral epithelia, 24 dysplastic oral leukoplakia (OLK), and 40 OSCC specimens, expressions of CXCL12 and CXCR4 were evaluated by immunohistochemistry.
RESULTS
CXCR4 was expressed in 37.5% of OLK and 60% of OSCC. CXCL12 was detected in 50% of OLK and 62.5% of OSCC. In OLK, CXCR4 positive ratio showed no significant difference from normal epithelia, but the CXCL12 positive ratio was significantly higher. Significant relationship between CXCL12 and CXCR4 was found both in OLK and OSCC.
CONCLUSION
Our results indicated that CXCL12/CXCR4 axis may play roles from early steps of oral malignant transformation and contribute to the progress of oral carcinogenesis.
目的
趋化因子受体 CXCR4 及其配体 CXCL12 被认为在癌症的发生或进展中发挥重要作用。本研究的目的是研究口腔癌前病变和口腔鳞状细胞癌（OSCC）中 CXCL12/CXCR4 的变化。
方法
在 13 例正常口腔上皮、24 例异型性口腔白斑（OLK）和 40 例 OSCC 标本中，采用免疫组织化学法检测 CXCL12 和 CXCR4 的表达。
结果
OLK 中有 37.5%和 OSCC 中有 60%表达 CXCR4。OLK 中检测到 50%的 CXCL12 和 OSCC 中 62.5%的 CXCL12。OLK 中 CXCR4 阳性率与正常上皮无显著差异，但 CXCL12 阳性率显著升高。OLK 和 OSCC 中均发现 CXCL12 与 CXCR4 之间存在显著相关性。
结论
我们的结果表明，CXCL12/CXCR4 轴可能在口腔恶性转化的早期阶段发挥作用，并有助于口腔癌变的进展。
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