Donald Paul J
University of California, Davis, School of Medicine, Department of Otolaryngology-Head and Neck Surgery, Sacramento, California.
Skull Base. 2006 May;16(2):67-74. doi: 10.1055/s-2006-931621.
To report our experience in the management of sinonasal undifferentiated carcinoma (SNUC) over a period of 15 years.
A retrospective case review of 13 patients with SNUC treated at the University of California, Davis, Medical Center (UCDMC) Center for Skull Base Surgery, over the past 15 years.
Most tumors arose in the ethmoid sinuses. All but 1 patient had a combined intracranial-extracranial resection through the anterior fossa-transcranial route and postoperative irradiation. The 13th patient had a transfacial subcranial approach. There are 6 who have survived free of disease at 14 years' to 8 months' follow-up. The average follow-up was 6 years, 3 months. One patient died of a pulmonary embolism in the first postoperative week, a second died of a bowel infarction 3 months postoperatively. Three patients died of their disease at 20, 18, and 8 months postoperatively: 1 with local recurrence and distant metastasis and the other 2 with local control but distant disease. The 6 survivors are at 8, 20, 28, 62, 84, and 105 months.
SNUC is a rare malignancy of the paranasal sinuses with a poor prognosis. Radical surgery and adjunctive therapy can achieve good survival in a significant proportion of patients who would hitherto have seemed incurable.
报告我们在15年期间治疗鼻窦未分化癌（SNUC）的经验。
对过去15年在加利福尼亚大学戴维斯分校医学中心（UCDMC）颅底外科中心治疗的13例SNUC患者进行回顾性病例分析。
大多数肿瘤起源于筛窦。除1例患者外，所有患者均通过前颅窝 - 经颅途径进行了颅内 - 颅外联合切除术及术后放疗。第13例患者采用经面部颅下入路。在14年至8个月的随访中有6例患者无病存活。平均随访时间为6年3个月。1例患者在术后第一周死于肺栓塞，另1例在术后3个月死于肠梗死。3例患者分别在术后20个月、18个月和8个月死于疾病：1例伴有局部复发和远处转移，另外2例局部得到控制但有远处疾病。6例幸存者的随访时间分别为8个月、20个月、28个月、62个月、84个月和105个月。
SNUC是一种罕见的鼻窦恶性肿瘤，预后较差。根治性手术和辅助治疗可使相当一部分原本看似无法治愈的患者获得良好的生存期。
