Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infection and Immunity Amsterdam (CINIMA) at the Academic Medical Center of the University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
J Transl Med. 2011 Jan 27;9 Suppl 1(Suppl 1):S5. doi: 10.1186/1479-5876-9-S1-S5.
The identification of phenotypically distinct HIV-1 variants with different prevalence during the progression of the disease has been one of the earliest discoveries in HIV-1 biology, but its relevance to AIDS pathogenesis remains only partially understood. The physiological basis for the phenotypic variability of HIV-1 was elucidated with the discovery of distinct coreceptors employed by the virus to infect susceptible cells. The role of the viral phenotype in the variable clinical course and treatment outcome of HIV-1 infection has been extensively investigated over the past two decades. In this review, we summarize the major findings on the clinical significance of the HIV-1 coreceptor usage.
在疾病进展过程中，鉴定表型不同、流行程度不同的 HIV-1 变异体是 HIV-1 生物学最早的发现之一，但它与艾滋病发病机制的关系仍部分未知。随着对病毒感染易感细胞所采用的不同核心受体的发现，阐明了 HIV-1 表型变异性的生理基础。在过去的二十年中，人们广泛研究了 HIV-1 感染的病毒表型在可变临床病程和治疗结果中的作用。在这篇综述中，我们总结了 HIV-1 核心受体使用的临床意义的主要发现。
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