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对克氏锥虫的免疫反应：Toll样受体的作用及疫苗开发前景

The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine Development.

作者信息

Rodrigues Mauricio M, Oliveira Ana Carolina, Bellio Maria

机构信息

Centro de Terapia Celular e Molecular (CTCMol), Universidade Federal de São Paulo (UNIFESP), 04044-010 São Paulo, SP, Brazil.

出版信息

J Parasitol Res. 2012;2012:507874. doi: 10.1155/2012/507874. Epub 2012 Feb 16.

DOI:10.1155/2012/507874
PMID:22496959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3306967/
Abstract

In the past ten years, studies have shown the recognition of Trypanosoma cruzi-associated molecular patterns by members of the Toll-like receptor (TLR) family and demonstrated the crucial participation of different TLRs during the experimental infection with this parasite. In the present review, we will focus on the role of TLR-activated pathways in the modulation of both innate and acquired immune responses to T. cruzi infection, as well as discuss the state of the art of vaccine research and development against the causative agent of Chagas disease (or American trypanosomiasis).

摘要

在过去十年中，研究表明Toll样受体（TLR）家族成员能够识别克氏锥虫相关分子模式，并证明了不同的TLR在该寄生虫实验性感染过程中的关键作用。在本综述中，我们将重点关注TLR激活途径在调节对克氏锥虫感染的固有免疫和获得性免疫反应中的作用，并讨论针对恰加斯病（或美洲锥虫病）病原体的疫苗研发现状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d75/3306967/3202e1384d07/JPR2012-507874.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d75/3306967/3202e1384d07/JPR2012-507874.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d75/3306967/3202e1384d07/JPR2012-507874.001.jpg

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