Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, SAR, China.
Semin Cancer Biol. 2012 Apr;22(2):137-43. doi: 10.1016/j.semcancer.2012.02.004.
EBV-associated human malignancies may originate from B cells and epithelial cells. EBV readily infects B cells in vitro and transforms them into proliferative lymphoblastoid cell lines. In contrast, infection of human epithelial cells in vitro with EBV has been difficult to achieve. The lack of experimental human epithelial cell systems for EBV infection has hampered the understanding of biology of EBV infection in epithelial cells. The recent success to infect human epithelial cells with EBV in vitro has allowed systematic investigations into routes of EBV entry, regulation of latent and lytic EBV infection, and persistence of EBV infection in infected epithelial cells. Understanding the biology of EBV infection in human epithelial cells will provide important insights to the role of EBV infection in the pathogenesis of EBV-associated epithelial malignancies including nasopharyngeal carcinoma and gastric carcinoma.
EBV 相关人类恶性肿瘤可能起源于 B 细胞和上皮细胞。EBV 可轻易在体外感染 B 细胞并将其转化为增殖性淋巴母细胞系。相比之下，在体外感染人类上皮细胞则较为困难。缺乏用于 EBV 感染的实验性人类上皮细胞系统，阻碍了对 EBV 感染上皮细胞的生物学特性的理解。最近，成功地在体外感染人类上皮细胞，使对 EBV 进入途径、潜伏和裂解性 EBV 感染的调控以及感染上皮细胞中 EBV 感染的持续存在进行系统研究成为可能。了解 EBV 感染人类上皮细胞的生物学特性，将为 EBV 感染在包括鼻咽癌和胃癌在内的 EBV 相关上皮性恶性肿瘤发病机制中的作用提供重要的见解。
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