爱泼斯坦-巴尔病毒与乳腺癌：证据与展望
Epstein-Barr Virus Association with Breast Cancer: Evidence and Perspectives.
作者信息
Arias-Calvachi Claudia, Blanco Rancés, Calaf Gloria M, Aguayo Francisco
机构信息
Programa de Virología, Laboratorio de Oncovirología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.
Instituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, Chile.
出版信息
Biology (Basel). 2022 May 24;11(6):799. doi: 10.3390/biology11060799.
Epstein-Barr virus (EBV) is an enveloped DNA virus that belongs to the gamma Herpesviridae family. The virus establishes a latent/lytic persistent infection, though it can be involved in cancer development in some subjects. Indeed, evidence supports an etiological role of EBV in undifferentiated nasopharyngeal carcinoma (NPC), a subset of gastric carcinomas and lymphomas. Additionally, EBV has been detected in breast carcinomas (BCs) although its role has not been established. In this review, we summarize epidemiological information regarding the presence of EBV in BC and we propose mechanistic models. However, additional epidemiological and experimental evidence is warranted to confirm these models.
爱泼斯坦-巴尔病毒（EBV）是一种包膜DNA病毒，属于γ疱疹病毒科。该病毒会建立潜伏/裂解性持续感染，尽管在某些个体中它可能参与癌症的发展。事实上，有证据支持EBV在未分化鼻咽癌（NPC）、一部分胃癌和淋巴瘤中具有病因学作用。此外，在乳腺癌（BC）中也检测到了EBV，但其作用尚未明确。在本综述中，我们总结了有关BC中EBV存在情况的流行病学信息，并提出了作用机制模型。然而，还需要更多的流行病学和实验证据来证实这些模型。
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