通过分子内狄尔斯-阿尔德反应和氧化脱芳构化-环化反应简洁构建皮质抑素氧杂五环核心的模型研究。
A model study for the concise construction of the oxapentacyclic core of cortistatins through intramolecular Diels-Alder and oxidative dearomatization-cyclization reactions.
作者信息
Liu Lianzhu, Gao Yingxiang, Che Chao, Wu Na, Wang David Zhigang, Li Chuang-Chuang, Yang Zhen
机构信息
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China.
出版信息
Chem Commun (Camb). 2009 Feb 14(6):662-4. doi: 10.1039/b817376a. Epub 2008 Dec 9.
DOI:10.1039/b817376a
PMID:19322414
Abstract
A unified strategy towards the facile construction of the [6.7.6.5] oxapentacyclic skeleton of cortistatins is reported, featuring intramolecular Diels-Alder (IMDA) and oxidative dearomatization-cyclization reactions as key steps.
摘要
报道了一种用于简便构建皮质抑素[6.7.6.5]氧杂五环骨架的统一策略，其关键步骤为分子内狄尔斯-阿尔德（IMDA）反应和氧化去芳构化-环化反应。
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