DairyNZ, Hamilton, New Zealand.
Anim Genet. 2012 Oct;43(5):591-4. doi: 10.1111/j.1365-2052.2011.02293.x. Epub 2011 Dec 7.
Variation at the pleiomorphic adenoma gene 1 (PLAG1) locus has recently been implicated in the regulation of stature and weight in Bos taurus. Using a population of 942 outbred Holstein-Friesian dairy calves, we report confirmation of this effect, demonstrating strong association of early life body weight with PLAG1 genotype. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype. Growth rate per kilogram of body weight, daily feed intake, gross feed efficiency and residual feed intake were not significantly associated with PLAG1 genotype. This study supports the status of PLAG1 as a key regulator of mammalian growth. Further, the data indicate the utility of PLAG1 polymorphisms for the selection of animals to achieve enhanced weight gain or conversely to aid the selection of animals with lower mature body weight and thus lower maintenance energy requirements.
多形性腺瘤基因 1 (PLAG1) 位点的变异最近被牵连到调控牛的身高和体重。利用一个 942 头杂交荷斯坦-弗里森奶牛的群体，我们报告了这种影响的确认，证明了生命早期体重与 PLAG1 基因型之间的强烈关联。围青春期体重和生长速度也与 PLAG1 基因型显著相关。体重每公斤生长速度、每日采食量、总饲料效率和剩余饲料摄入量与 PLAG1 基因型无显著关联。本研究支持 PLAG1 作为哺乳动物生长关键调节剂的地位。此外，这些数据表明 PLAG1 多态性可用于选择动物，以实现体重的增加，或者相反，选择具有较低成熟体重和较低维持能量需求的动物。
