Adams Anthony J, Bearse Marcus A
School of Optometry, University of California at Berkeley, Berkeley, CA 94720-2020, USA.
Clin Exp Optom. 2012 May;95(3):256-65. doi: 10.1111/j.1444-0938.2012.00733.x. Epub 2012 Apr 13.
Diabetes, now at epidemic levels, can have devastating effects on the eye and vision. Treatments of the ocular complications are currently focused on relatively advanced stages and are limited to the slowing down of the progressive sight-threatening retinal vasculopathy (diabetic retinopathy). Tiny signals from the neural retina have been shown to reveal early diabetic neuropathy prior to vascular retinopathy. These signals, in a clinical test format, are predictive, by precise retinal location, of impending vasculopathy in the retina within a year, including sight-threatening oedema. The discovery opens possibilities for the future development of treatments to prevent the onset of retinopathy and the more sight-threatening retinal oedema and changes patient management strategies.
糖尿病目前已呈流行态势，可对眼睛和视力造成毁灭性影响。眼部并发症的治疗目前集中在相对晚期阶段，并且仅限于减缓进展性威胁视力的视网膜血管病变（糖尿病性视网膜病变）。已证明来自神经视网膜的微小信号可在血管性视网膜病变之前揭示早期糖尿病性神经病变。这些信号以临床测试形式，通过精确的视网膜位置，可预测一年内视网膜即将发生的血管病变，包括威胁视力的水肿。这一发现为未来开发预防视网膜病变和更具视力威胁性的视网膜水肿的治疗方法开辟了可能性，并改变了患者管理策略。
