用四环吲哚克服白念珠菌临床分离株的氟康唑耐药性。
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.
机构信息
Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.
出版信息
Bioorg Med Chem Lett. 2012 May 1;22(9):3362-5. doi: 10.1016/j.bmcl.2012.02.035. Epub 2012 Feb 22.
Abstract
Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.
摘要
为了寻找新的方法来对抗白色念珠菌对氟康唑的耐药性，研究人员发现了一种吲哚衍生物，它可以使对氟康唑耐药的菌株变得敏感。这种四环化合物（3，ML229）似乎并没有通过已建立的 Hsp90 或钙调磷酸酶途径来使酿酒酵母模型中的白色念珠菌产生化疗敏感性，因此它可能是一种有用的探针，可以揭示替代的耐药途径。
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