Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
Schizophr Res. 2012 Jun;138(1):69-73. doi: 10.1016/j.schres.2012.03.007. Epub 2012 Apr 11.
A recent study found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating evidence that BD and schizophrenia partly share genetic risk factors, we tested this single-nucleotide polymorphism for association with schizophrenia in three independent patient-control samples of European ancestry, totaling 5061 patients and 9655 controls. The rs1064395 A-allele, which confers risk for BD, was significantly over-represented in schizophrenia patients compared to controls (p=2.28×10(-3); odds ratio=1.11). Follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium (5537 patients, 8043 controls) provided further support for our finding (p=0.0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia.
最近的一项研究发现，神经钙黏蛋白（NCAN，rs1064395）基因中的常见变异与双相情感障碍（BD）之间存在全基因组显著关联。鉴于越来越多的证据表明 BD 和精神分裂症部分共享遗传风险因素，我们在三个独立的欧洲血统的患者-对照样本中测试了这种单核苷酸多态性与精神分裂症的关联，总共有 5061 名患者和 9655 名对照。与对照组相比，BD 的风险等位基因 rs1064395 的 A 等位基因在精神分裂症患者中明显过多（p=2.28×10(-3)；优势比=1.11）。来自精神分裂症精神疾病 GWAS 联盟的非重叠样本的后续研究（5537 名患者，8043 名对照）进一步支持了我们的发现（p=0.0239，优势比=1.07）。我们的数据表明，NCAN 中的遗传变异是 BD 和精神分裂症的常见风险因素。
