Mohamedi Yamina, Fontanil Tania, Cal Santiago, Cobo Teresa, Obaya Álvaro J
Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, Oviedo, Spain.
Departamento de Investigación, Instituto Ordóñez, Oviedo, Spain.
Front Mol Biosci. 2021 Apr 30;8:686763. doi: 10.3389/fmolb.2021.686763. eCollection 2021.
Nineteen members of the ADAMTS family of secreted zinc metalloproteinases are present in the human degradome. A wide range of different functions are being attributed to these enzymes and the number of their known substrates is considerably increasing in recent years. ADAMTSs can participate in processes such as fertility, inflammation, arthritis, neuronal and behavioral disorders, as well as cancer. Since its first annotation in 2001, ADAMTS-12 has been described to participate in different processes displayed by members of this family of proteinases. In this sense, ADAMTS-12 performs essential roles in modulation and recovery from inflammatory processes such as colitis, endotoxic sepsis and pancreatitis. ADAMTS-12 has also been involved in cancer development acting either as a tumor suppressor or as a pro-tumoral agent. Furthermore, participation of ADAMTS-12 in arthritis or in neuronal disorders has also been suggested through degradation of components of the extracellular matrix. In addition, ADAMTS-12 proteinase activity can also be modified by interaction with other proteins and thus, can be an alternative way of modulating ADAMTS-12 functions. In this review we revised the most relevant findings about ADAMTS-12 function on the 20th anniversary of its identification.
分泌型锌金属蛋白酶ADAMTS家族的19个成员存在于人类降解组中。近年来，这些酶被赋予了广泛多样的功能，其已知底物的数量也在大幅增加。ADAMTS可参与生育、炎症、关节炎、神经及行为障碍以及癌症等过程。自2001年首次注释以来，ADAMTS - 12已被描述为参与该蛋白酶家族成员所表现出的不同过程。从这个意义上讲，ADAMTS - 12在诸如结肠炎、内毒素血症和胰腺炎等炎症过程的调节和恢复中发挥着重要作用。ADAMTS - 12还通过作为肿瘤抑制因子或促肿瘤因子参与癌症发展。此外，通过降解细胞外基质成分，也有人提出ADAMTS - 12参与关节炎或神经疾病。此外，ADAMTS - 12蛋白酶活性也可通过与其他蛋白质相互作用而改变，因此，这可能是调节ADAMTS - 12功能的另一种方式。在这篇综述中，我们在ADAMTS - 12被鉴定20周年之际，回顾了有关其功能的最相关研究发现。
