Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy.
J Viral Hepat. 2012 May;19(5):307-15. doi: 10.1111/j.1365-2893.2012.01592.x.
Neuropsychological assessment has three main applications in clinical hepatology: (i) to detect, grade and monitor liver failure-related cognitive alterations in end-stage liver disease (hepatic encephalopathy), (ii) to substantiate complaints of attention or concentration difficulties in patients with non-cirrhotic chronic hepatitis C viral infection, and (iii) to screen patients who are being considered for liver transplantation for early signs of dementia. However, there is limited agreement on how cognitive assessment should be conducted in these patients, and how results should be interpreted and used to implement clinical decisions. In this review, we summarize the available literature on neuropsychological dysfunction in patients with cirrhosis and with chronic hepatitis C viral infection and provide some guidance on how to utilize neuropsychological assessment in practice.
（i）在终末期肝病（肝性脑病）中检测、分级和监测与肝功能衰竭相关的认知改变，（ii）证实非肝硬化丙型肝炎病毒感染患者注意力或集中力困难的主诉，以及（iii）筛选考虑进行肝移植的患者，以发现痴呆的早期迹象。然而，对于如何在这些患者中进行认知评估，以及如何解释和使用评估结果来做出临床决策，尚未达成共识。在这篇综述中，我们总结了关于肝硬化和慢性丙型肝炎病毒感染患者神经心理功能障碍的现有文献，并就如何在实践中利用神经心理学评估提供了一些指导。
