Louvain Centre for Toxicology and Applied Pharmacology, Université catholique de Louvain (Brussels), Avenue Mounier 53.02, B-1200, Belgium.
Neurotoxicology. 2012 Aug;33(4):872-80. doi: 10.1016/j.neuro.2012.03.009. Epub 2012 Apr 3.
This symposium comprised five oral presentations dealing with recent findings on Mn-related cognitive and motor changes from epidemiological studies across the life span. The first contribution highlighted the usefulness of functional neuroimaging of the central nervous system (CNS) to evaluate cognitive as well as motor deficits in Mn-exposed welders. The second dealt with results of two prospective studies in Mn-exposed workers or welders showing that after decrease of Mn exposure the outcome of reversibility in adverse CNS effects may differ for motor and cognitive function and, in addition the issue of plasma Mn as a reliable biomarker for Mn exposure in welders has been addressed. The third presentation showed a brief overview of the results of an ongoing study assessing the relationship between environmental airborne Mn exposure and neurological or neuropsychological effects in adult Ohio residents living near a Mn point source. The fourth paper focused on the association between blood Mn and neurodevelopment in early childhood which seems to be sensitive to both low and high Mn concentrations. The fifth contribution gave an overview of six studies indicating a negative impact of excess environmental Mn exposure from air and drinking water on children's cognitive performance, with special attention to hair Mn as a potential biomarker of exposure. These studies highlight a series of questions about Mn neurotoxicity with respect to cognitive processes, forms and routes of exposure, adequate biomarkers of exposure, gender differences, susceptibility and exposure limits with regard to age.
本次研讨会由五场口头报告组成，内容涉及全生命周期内流行病学研究中与锰相关的认知和运动变化的最新发现。第一项研究贡献强调了中枢神经系统（CNS）功能神经影像学在评估接触锰的焊工的认知和运动缺陷方面的有用性。第二项研究涉及两项针对接触锰的工人或焊工的前瞻性研究的结果，表明在减少锰暴露后，对不良 CNS 影响的逆转结果可能因运动和认知功能而有所不同，此外，还探讨了血浆锰作为焊工锰暴露的可靠生物标志物的问题。第三项研究简要介绍了一项正在进行的研究的结果，该研究评估了俄亥俄州居住在锰点源附近的成年居民环境空气中的锰暴露与神经或神经心理学影响之间的关系。第四项研究聚焦于血液锰与儿童早期神经发育之间的关系，该关系似乎对低浓度和高浓度锰都敏感。第五项研究综述了六项研究，这些研究表明，来自空气和饮用水的过量环境锰暴露对儿童的认知表现有负面影响，特别关注头发锰作为暴露的潜在生物标志物。这些研究强调了一系列关于锰神经毒性的问题，涉及认知过程、暴露形式和途径、暴露的适当生物标志物、性别差异、易感性和暴露限度以及年龄问题。
