Department of Rheumatology, Merlin Park University Hospital, Galway, Ireland.
J Clin Gastroenterol. 2012 May-Jun;46(5):407-12. doi: 10.1097/MCG.0b013e3182485528.
We determined the prevalence of fibromyalgia syndrome (FMS) in a cohort of subjects with chronic hepatitis C virus (HCV), and the relationship to subject demographics, viral characteristics, and quality of life.
In a cross-sectional study of a cohort of HCV-infected individuals, all subjects underwent a standard assessment including history, clinical examination, and functional assessments for pain and disability.
A total of 185 subjects met the inclusion criteria. Median age was 48.7 years, and 110 (59%) were women. A total of 106 (57%) of the subjects met criteria for the presence of FMS. Widespread pain and ≥11 tender points were present in all of the subjects with FMS, fatigue in 98 (92%), and depression in 60 (57%). Among those with FMS, mean pain score was 70±11.78 and 36% reported some functional impairment on (HAQ-DI>0), with 17% reporting moderate-to-severe functional impairment (HAQ-DI≥1.5).
This study reveals a high prevalence of FMS (57%) among subjects with chronic HCV infection, one third of whom reported some degree of functional impairment. Recognition and management of this condition in such patients will help improve their quality of life.
我们在慢性丙型肝炎病毒（HCV）感染患者队列中确定了纤维肌痛综合征（FMS）的患病率，并研究其与患者人口统计学特征、病毒特征和生活质量的关系。
在一项对 HCV 感染个体队列的横断面研究中，所有患者均接受了标准评估，包括病史、临床检查以及疼痛和残疾的功能评估。
共有 185 名患者符合纳入标准。中位年龄为 48.7 岁，110 名（59%）为女性。共有 106 名（57%）患者符合 FMS 的存在标准。所有患有 FMS 的患者均存在广泛疼痛和≥11 个压痛点，98 名（92%）患者存在疲劳，60 名（57%）患者存在抑郁。在患有 FMS 的患者中，疼痛评分平均值为 70±11.78，36%的患者（HAQ-DI>0）报告存在一定程度的功能障碍，17%的患者（HAQ-DI≥1.5）报告存在中度至重度功能障碍。
本研究显示慢性 HCV 感染患者中 FMS 的患病率较高（57%），其中三分之一的患者报告存在一定程度的功能障碍。在这些患者中识别和管理这种情况有助于提高他们的生活质量。
