Gubanova N B, Karakulova Iu V
Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(10 Pt 2):20-2.
Psychoemotional status and blood serotonin level were investigated in 69 patients with different forms of idiopathic epilepsy during the seizures and interictal period. Twenty-two patients with juvenile myoclonic epilepsy, 22 patients with absence forms and 22 patients with generalized convulsive seizures, aged 10-47 years, were included in the study. We found the significant decrease in blood serotonin levels during the interictal period, with the lower levels seen after generalized convulsive and myoclonic seizures. After the treatment with antidepressant fluvoxamine as add-on treatment, 16 patients revealed improved psychoemotional well-being and quality of life as well as a decreased number of generalized convulsive seizures along with the increasing of blood serotonin level.
对69例不同类型特发性癫痫患者在发作期和发作间期的心理情绪状态及血液血清素水平进行了研究。研究纳入了22例青少年肌阵挛性癫痫患者、22例失神发作型患者和22例全身惊厥性发作患者，年龄在10至47岁之间。我们发现发作间期血液血清素水平显著降低，全身惊厥性发作和肌阵挛性发作后水平更低。在加用抗抑郁药氟伏沙明治疗后，16例患者的心理情绪幸福感和生活质量得到改善，全身惊厥性发作次数减少，同时血液血清素水平升高。
