I. Med. Klinik und Poliklinik, Johannes Gutenberg Universität Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
Gastroenterol Clin North Am. 2012 Jun;41(2):291-302. doi: 10.1016/j.gtc.2012.01.016.
Chromoendoscopy with methylene blue or indigo carmine significantly increases the diagnostic yield of finding intraepithelial neoplasia in patients with longstanding colitis. The number needed to treat is 14 for panchromoendoscopy to identify 1 additional patient with dysplasia. Chromoendoscopy can greatly facilitate the identification of flat lesions harboring intraepithelial neoplasia. Chromoendoscopy can guide biopsies and clearly reduces the amount of biopsies that are needed per patient. Magnifying endoscopy or CLE are additional techniques, which can be used in conjunction with chromoendoscopy to further reduce the amount of biopsies and to further increase the diagnostic yield. Chromoendoscopy is an established clinical procedure and recommended by many gastroenterological societies for surveillance of patients with longstanding ulcerative colitis. Thus, intravital staining should be an essential part of the diagnostic armamentarium of every colonoscopist.
亚甲蓝或靛胭脂染色内镜显著提高了对长期结肠炎患者上皮内瘤变的诊断率。全染色内镜检查每增加 1 例异型增生患者，需要治疗的人数为 14。染色内镜可极大地促进对平坦病变中上皮内瘤变的识别。染色内镜可指导活检，并明显减少每位患者所需的活检数量。放大内镜或 CLE 是另外两种技术，可与染色内镜联合使用，进一步减少活检数量，并进一步提高诊断率。染色内镜是一种成熟的临床操作程序，被许多胃肠病学会推荐用于长期溃疡性结肠炎患者的监测。因此，活体内染色应该是每个结肠镜医生诊断工具的重要组成部分。
