Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
Immunol Rev. 2012 May;247(1):133-42. doi: 10.1111/j.1600-065X.2012.01117.x.
T-cell help to B cells is a fundamental aspect of adaptive immunity and the generation of B-cell memory (memory B cells and plasma cells). Follicular helper CD4(+) T (Tfh) cells are the specialized providers of B-cell help, and Tfh cells depend on Bcl6 for their differentiation. This review discusses Tfh cell functions, transcription factors, and induction signals, with particular focus on the richness of the underlying biology and assessing the simplicity or complexity of each of these processes.
T 细胞辅助 B 细胞是适应性免疫和 B 细胞记忆（记忆 B 细胞和浆细胞）产生的一个基本方面。滤泡辅助性 CD4(+)T（Tfh）细胞是 B 细胞辅助的专门提供者，Tfh 细胞依赖 Bcl6 进行分化。本文讨论了 Tfh 细胞的功能、转录因子和诱导信号，特别关注了这些过程背后生物学的复杂性，并评估了每个过程的简单或复杂程度。
