Ichinose H, Powell L, Hoerner H E, Derbes V J, Byers J F
Cancer Res. 1979 Oct;39(10):4270-3.
The belief that synoviomas differentiate from the synovial membrane has been widely accepted. Absolute proof is lacking, mainly because precancerous synovial atypia has not been documented in human tissue. During the last 50 years, pain has emerged as one of the significant features of synovioma, occurring very early in the course of the disease in some patients. Gross relationship to nerve, cumulative histological data, and theoretical relationships with three other cancers of neural origin suggest the nerve sheath as an alternate parent tissue for synovioma. Three cases illustrating nerve involvement are included.
滑膜肉瘤起源于滑膜的观点已被广泛接受。但缺乏确凿证据，主要是因为在人体组织中尚未记录到癌前滑膜异型性。在过去50年里，疼痛已成为滑膜肉瘤的显著特征之一，在某些患者疾病过程中出现得非常早。与神经的大体关系、累积的组织学数据以及与其他三种神经源性癌症的理论关系表明，神经鞘可能是滑膜肉瘤的另一种起源组织。本文纳入了3例说明神经受累情况的病例。
