Behavioral and Social Neuroscience Research Group, CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Cortex. 2012 Oct;48(9):1240-3. doi: 10.1016/j.cortex.2012.03.004. Epub 2012 Mar 14.
Déjà vu (DV) is a widespread, fascinating and mysterious human experience. It occurs both in health and in disease, notably as an aura of temporal lobe epilepsy. This feeling of inappropriate familiarity has attracted interest from psychologists and neuroscientists for over a century, but still there is no widely agreed explanation for the phenomenon of non-pathological DV. Here we investigated differences in brain morphology between healthy subjects with and without DV using a novel multivariate neuroimaging technique, Source-Based Morphometry. The analysis revealed a set of cortical (predominantly mesiotemporal) and subcortical regions in which there was significantly less gray matter in subjects reporting DV. In these regions gray matter volume was inversely correlated with the frequency of DV. Our results demonstrate a structural correlate of DV in healthy individuals for the first time and support a neurological explanation for the phenomenon. We hypothesis that the observed local gray matter decrease in subjects experiencing DV reflects an alteration of hippocampal function and postnatal neurogenesis with resulting changes of volume in remote brain regions.
记忆错觉（Déjà vu，DV）是一种广泛存在、令人着迷且神秘的人类体验。它既存在于健康人群中，也存在于疾病患者中，特别是作为颞叶癫痫的先兆。这种不适当的熟悉感引起了心理学家和神经科学家一个多世纪以来的兴趣，但对于非病理性记忆错觉现象仍没有普遍认同的解释。在这里，我们使用一种新的多变量神经影像学技术——基于源的形态测量学，研究了健康人群中存在和不存在记忆错觉的个体之间的大脑形态差异。分析显示，在报告存在记忆错觉的受试者中，存在一组皮质（主要是内侧颞叶）和皮质下区域的灰质明显减少。在这些区域，灰质体积与记忆错觉的频率呈负相关。我们的研究结果首次证明了健康个体中记忆错觉存在结构相关性，并为该现象提供了神经学解释。我们假设，经历记忆错觉的受试者中观察到的局部灰质减少反映了海马功能的改变和出生后神经发生，导致远距离脑区的体积发生变化。
