Qiu Jiang, Xia Yunman, He Li, Chen Qunlin, Sang Na, Liu Wei, Li Hong
College of Education Science, ChengDu University, ChengDu, 610106, China; School of Psychology, Southwest University, Chongqing, 400715, China.
School of Psychology, Southwest University, Chongqing, 400715, China.
Biol Psychol. 2018 Mar;133:72-78. doi: 10.1016/j.biopsycho.2018.02.001. Epub 2018 Feb 6.
How déjà vu works has long been a mystery, partially because of its characteristics of unpredictable occurrences and quick disappearances, which make it difficult to be explored. Previous studies have described the anatomical structures underlying déjà vu in healthy subjects; however, the functional mechanism of déjà vu remains unclear. Therefore, this study investigated the brain structural and functional components underlying déjà vu by combining voxel-based morphometry analysis (VBM) with resting-state functional connectivity (rsFC). The VBM analysis revealed that the anterior parahippocampal gyrus (PHG) had significantly less grey matter volume (GMV) in high déjà vu group than low group, confirming previous studies. Further functional connectivity analysis revealed that the frequency of déjà vu experiences was negatively correlated with the strength of the rsFC between anterior dorsal lateral prefrontal cortex (DLPFC) and anterior PHG but positively correlated with the strength of the rsFC between posterior DLPFC and posterior PHG. Moreover, the frequency of déjà vu experiences was negatively correlated with the strength of the rsFC between the anterior and posterior regions of the PHG. These findings indicated that familiarity without recollection (PHG) and superior context monitoring (DLPFC) are critical for real-life déjà vu experiences.
既视感的产生机制长期以来一直是个谜，部分原因在于其具有不可预测的出现和迅速消失的特点，这使得它难以被探究。以往的研究已经描述了健康受试者中既视感背后的解剖结构；然而，既视感的功能机制仍不清楚。因此，本研究通过将基于体素的形态计量学分析（VBM）与静息态功能连接（rsFC）相结合，研究了既视感背后的脑结构和功能成分。VBM分析显示，高既视感组的前海马旁回（PHG）灰质体积（GMV）显著少于低既视感组，证实了以往的研究。进一步的功能连接分析显示，既视感体验的频率与前背外侧前额叶皮层（DLPFC）和前PHG之间的rsFC强度呈负相关，但与后背外侧前额叶皮层和后PHG之间的rsFC强度呈正相关。此外，既视感体验的频率与PHG前后区域之间的rsFC强度呈负相关。这些发现表明，无回忆的熟悉感（PHG）和高级情境监测（DLPFC）对于现实生活中的既视感体验至关重要。
