Department of Pediatric Surgery, University Hospital Split and Split University School of Medicine, Spinčićeva 1, 21 000 Split, Croatia.
J Pediatr Urol. 2013 Jun;9(3):313-7. doi: 10.1016/j.jpurol.2012.03.009. Epub 2012 Apr 12.
The differential diagnosis of an acute scrotum is of great importance in clinical practice and may be difficult in some cases. The aim of this study was to differentiate inflammatory from non-inflammatory causes of acute scrotum using relatively simple laboratory tests which can be performed quickly and easily outside a hospital setting.
From 2007 to 2010, 85 boys with acute scrotum were included in this prospective study. There were 28 boys with inflammatory and 57 with non-inflammatory causes. We investigated the role of erythrocyte sedimentation rate, C-reactive protein, leukocyte, white blood cell differential count, alkaline phosphatase, creatine kinase and child's age in differential diagnosis of the acute scrotum, differentiating inflammatory from non-inflammatory causes of the disease. We used receiver operating characteristics (ROC) analysis and logistic regression analysis.
Statistically significant parameters in accurate differentiation between inflammatory and non-inflammatory causes of the acute scrotum were C-reactive protein (p = 0.001) and child's age (p < 0.001). These two parameters yielded the probability of an inflammatory outcome in the etiology of acute scrotum with sensitivity of 75% and specificity of 69.1%.
C-reactive protein and child's age are helpful in differentiating inflammatory from non-inflammatory causes of the acute scrotum.
急性阴囊的鉴别诊断在临床实践中非常重要，在某些情况下可能较为困难。本研究旨在使用相对简单的实验室检查来区分急性阴囊的炎症和非炎症原因，这些检查可以在医院外快速、简便地进行。
从 2007 年到 2010 年，共有 85 名急性阴囊患儿纳入本前瞻性研究。其中 28 名患儿为炎症性病因，57 名患儿为非炎症性病因。我们研究了红细胞沉降率、C 反应蛋白、白细胞、白细胞分类计数、碱性磷酸酶、肌酸激酶和患儿年龄在急性阴囊鉴别诊断中的作用，以区分疾病的炎症性和非炎症性病因。我们使用了受试者工作特征（ROC）分析和逻辑回归分析。
在准确区分急性阴囊的炎症性和非炎症性病因方面，有统计学意义的参数是 C 反应蛋白（p=0.001）和患儿年龄（p<0.001）。这两个参数在急性阴囊病因的炎症结果中具有 75%的敏感性和 69.1%的特异性。
C 反应蛋白和患儿年龄有助于区分急性阴囊的炎症性和非炎症性病因。
