Ishii Y
First Department of Surgery, Juntendo University, School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1990 Oct;87(10):2333-41.
Vagally innervated antral pouches were created in adult mongrel dogs, the interiors of these antral pouches were perfused with glycocholate, taurocholate, canine bile and human pancreatic juice, and antral function was investigated from the viewpoint of gastric endocrine and exocrine response. Perfusion with glycocholate and taurocholate of 20 mM induced a significant increase in gastric acid secretion as well as serum gastrin secretory response. Perfusion with canine bile and human pancreatic juice induced a pronounced increase in serum gastrin levels as well as gastric acid secretion starting immediately after the beginning of perfusion, and serum gastrin secretory response also displayed a marked increase. These results demonstrated that the regurgitation into the stomach of duodenal fluid containing bile and pancreatic juice, constitutes one factor causing increased serum gastrin levels and gastric acid secretion.
在成年杂种犬中创建了由迷走神经支配的胃窦袋，向这些胃窦袋内部灌注甘氨胆酸盐、牛磺胆酸盐、犬胆汁和人胰液，并从胃内分泌和外分泌反应的角度研究胃窦功能。用20 mM的甘氨胆酸盐和牛磺胆酸盐灌注可显著增加胃酸分泌以及血清胃泌素分泌反应。用犬胆汁和人胰液灌注可使血清胃泌素水平以及胃酸分泌从灌注开始后立即显著增加，血清胃泌素分泌反应也显著增加。这些结果表明，含有胆汁和胰液的十二指肠液反流至胃内是导致血清胃泌素水平升高和胃酸分泌增加的一个因素。
