Yagi Y, Misumi A, Murakami A
Gastroenterol Jpn. 1984 Feb;19(1):24-33. doi: 10.1007/BF02774643.
This study was performed to investigate the mechanisms and significance of the intestinal phase of gastric secretion. With infusion of 10% liver extract into the duodenum of dogs, serum gastrin levels of the right gastroepiploic vein increased significantly (p less than 0.01). With infusion of the pH 7.0 liver extract, acid and pepsin outputs in non- antrectomized dogs increased significantly (p less than 0.01), as did serum gastrin levels (p less than 0.01). Post-infusion acid output in these dogs was 48 +/- 16% of tetragastrin-stimulated output. With the same infusion, antrectomized dogs showed no significant increase of acid and pepsin outputs and serum gastrin levels. Acid output and serum gastrin levels in non- antrectomized dogs that were infused with pH 2.0 liver extract did not increase significantly. The values of almost all serum amino acids in both types of dogs increased slightly, but insignificantly, with pH 7.0 liver extract. We obtained the following conclusions. The intestinal phase of gastric secretion operates by the mediation of the antral mucosa, from which gastrin is released. Although this phase has some effect, the acid-secretory ability of this phase is masked by inhibitory systems under certain physical conditions.
本研究旨在探讨胃分泌肠期的机制及意义。向犬十二指肠内注入10%肝提取物后，胃网膜右静脉血清胃泌素水平显著升高（p<0.01）。注入pH 7.0肝提取物后，未行胃窦切除术的犬胃酸和胃蛋白酶分泌量显著增加（p<0.01），血清胃泌素水平亦显著升高（p<0.01）。这些犬注入后胃酸分泌量为四肽胃泌素刺激分泌量的48±16%。相同注入情况下，行胃窦切除术的犬胃酸和胃蛋白酶分泌量及血清胃泌素水平未见显著升高。向未行胃窦切除术的犬注入pH 2.0肝提取物后，胃酸分泌量和血清胃泌素水平未显著升高。两种犬注入pH 7.0肝提取物后，几乎所有血清氨基酸值均略有升高，但无显著意义。我们得出以下结论。胃分泌肠期通过胃窦黏膜介导发挥作用，胃窦黏膜释放胃泌素。尽管此期有一定作用，但在某些生理条件下，该期的胃酸分泌能力被抑制系统所掩盖。
