Faculty of Science, Department of Physics and Technology, University of Tromsø, Tromsø, Norway.
Phys Med Biol. 2012 May 7;57(9):2633-52. doi: 10.1088/0031-9155/57/9/2633. Epub 2012 Apr 13.
A new scheme for detection of vesicoureteral reflux (VUR) in children has recently been proposed in the literature. The idea is to warm bladder urine via microwave exposure to at least fever temperatures and observe potential urine reflux from the bladder back to the kidney(s) by medical radiometry. As a preliminary step toward realization of this detection device, we present non-invasive temperature monitoring by use of microwave radiometry in adults to observe temperature dynamics in vivo of a water-filled balloon placed within the oral cavity. The relevance of the approach with respect to detection of VUR in children is motivated by comparing the oral cavity and cheek tissue with axial CT images of young children in the bladder region. Both anatomical locations reveal a triple-layered tissue structure consisting of skin-fat-muscle with a total thickness of about 8-10 mm. In order to mimic variations in urine temperature, the target balloon was flushed with water coupled to a heat exchanger, that was moved between water baths of different temperatures, to induce measurable temperature gradients. The applied radiometer has a center frequency of 3.5 GHz and provides a sensitivity (accuracy) of 0.03 °C for a data acquisition time of 2 s. Three different scenarios were tested and included observation through the cheek tissue with and without an intervening water bolus compartment present. In all cases, radiometric readings observed over a time span of 900 s were shown to be highly correlated (R ~ 0.93) with in situ temperatures obtained by fiberoptic probes.
最近文献中提出了一种新的小儿膀胱输尿管反流(VUR)检测方案。该方案的思路是通过微波照射将膀胱尿液加热到至少发热温度,并通过医疗辐射测量来观察潜在的尿液从膀胱反流到肾脏。作为实现这种检测设备的初步步骤,我们展示了成年人使用微波辐射测量的非侵入性温度监测,以观察位于口腔内充满水的气球的体内温度动态。该方法与小儿 VUR 检测的相关性是通过将口腔和颊组织与小儿膀胱区域的轴向 CT 图像进行比较得出的。这两个解剖位置都显示出由皮肤-脂肪-肌肉组成的三层组织结构,总厚度约为 8-10 毫米。为了模拟尿液温度的变化,目标气球通过与热交换器耦合的水冲洗,在不同温度的水浴之间移动,以产生可测量的温度梯度。所应用的辐射计的中心频率为 3.5 GHz,对于 2 s 的数据采集时间,其灵敏度(精度)为 0.03°C。测试了三种不同的情况,包括通过颊组织进行观察,以及存在和不存在中间水腔室的情况。在所有情况下,在 900 s 的时间跨度内观察到的辐射计读数与通过光纤探头获得的原位温度高度相关(R~0.93)。