Takada K
Department of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan.
Drug Discov Ther. 2008 Jun;2(3):140-55.
As a result of recent advances in microfabrication technology (MFT), microparticles including microcapsules and microspheres can be prepared individually and the disadvantages of the conventional microparticles produced by batch production, i.e. (i) low loading efficiency, (ii) large size variation, and (iii) initial burst release, have been remedied. In addition, all conventional microparticles have the same structure, a spherical shape, so they have only one function, sustained release. Threelayer microcapsules (TLMCs) have been designed to address these issues. TLMCs consist of a surface layer, a drug carrying layer, and a basement layer. TLMCs have sustained release as well as adhesiveness and targeting functions. TLMCs are prepared using ink-jet printer nozzle technology. The obtained TLMCs are used for the oral delivery of peptide/protein drugs and long-term sustained-release injection preparation. In addition, self-dissolving micropiles (SDMPs) can be individually produced by MFT as a percutaneous preparation. MFT allows biopharmaceutical drugs like insulin, erythropoietin, and growth hormone to be absorbed through the skin. Thus, advances in MFT have accelerated the development of pharmaceutical technology.
由于微制造技术（MFT）的最新进展，可以单独制备包括微胶囊和微球在内的微粒，并且传统批量生产的微粒所存在的缺点，即（i）低负载效率、（ii）大尺寸变化和（iii）初始突释，已得到弥补。此外，所有传统微粒都具有相同的结构，即球形，因此它们只有一种功能，即缓释。三层微胶囊（TLMC）已被设计用于解决这些问题。TLMC由表层、载药层和基层组成。TLMC具有缓释以及粘附和靶向功能。TLMC使用喷墨打印机喷嘴技术制备。所获得的TLMC用于肽/蛋白质药物的口服给药和长期缓释注射制剂。此外，自溶性微堆（SDMP）可以通过MFT单独生产作为经皮制剂。MFT使胰岛素、促红细胞生成素和生长激素等生物制药药物能够通过皮肤吸收。因此，MFT的进展加速了制药技术的发展。
