State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Ageing Res Rev. 2013 Jan;12(1):1-7. doi: 10.1016/j.arr.2012.03.006. Epub 2012 Apr 6.
Stem cell-based therapy is a promising option for the treatment of ischemic heart diseases. As to a successful stem cell-based therapy, one of the most important issues is that the stable engraftment and survival of implanted stem cells in cardiac microenvironment. There are evidences suggest that pharmacological treatment devoted to regulate stem cell function might represent a potential new therapeutic strategy and are drawing nearer to becoming a part of treatment in clinical settings. Statins could exert cholesterol-independent or pleiotropic effects to cardiovascular system. Recent studies have shown that statins could modulate the biological characteristics and function of various stem cells, thus could be an effective method to facilitate stem cell therapy. This review will focus on statins and their modulation effects on various stem cells.
基于干细胞的治疗是治疗缺血性心脏病的一种很有前途的选择。对于成功的基于干细胞的治疗，最重要的问题之一是植入的干细胞在心脏微环境中的稳定植入和存活。有证据表明，致力于调节干细胞功能的药物治疗可能代表一种潜在的新治疗策略，并正在接近成为临床治疗的一部分。他汀类药物可以发挥非胆固醇依赖性或多效性作用于心血管系统。最近的研究表明，他汀类药物可以调节各种干细胞的生物学特性和功能，因此可能是促进干细胞治疗的有效方法。这篇综述将重点介绍他汀类药物及其对各种干细胞的调节作用。
