Shah H C, Tatke P, Singh K K
C.U.Shah College of Pharmacy, S.N.D.T. Women's University, Mumbai, India.
Drug Discov Ther. 2008 Aug;2(4):200-10.
In recent years, there is a development of vaginal contraceptives incorporating potent spermicides. Many compounds with different pharmacological activity have been evaluated in vitro for their spermicidal activity. Drugs such as surfaceactive agents (synthetic and natural), ionophores, antiliquefying agents, antimicrobial agents and miscellaneous agents such as gossypol, Azadirachta indica, vanadocenes have all been demonstrated to possess good spermicidal activity. Nonoxynol is the only spermicidal agent currently marketed and widely used. But there is still a need to develop alternative compounds for future use as safe spermicide.
近年来，含强效杀精剂的阴道避孕药不断发展。许多具有不同药理活性的化合物已在体外评估其杀精活性。诸如表面活性剂（合成的和天然的）、离子载体、抗液化剂、抗菌剂以及诸如棉酚、印楝、钒多烯等其他各类制剂均已证明具有良好的杀精活性。壬苯醇醚是目前市面上销售并广泛使用的唯一杀精剂。但仍有必要研发可供未来用作安全杀精剂的替代化合物。
