• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗原特异性白细胞介素 2 分泌与坦桑尼亚儿童接种 RTS,S/AS01 疟疾疫苗后的 NK 细胞反应相关。

Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine.

机构信息

Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.

出版信息

J Immunol. 2012 May 15;188(10):5054-62. doi: 10.4049/jimmunol.1102710. Epub 2012 Apr 13.

DOI:10.4049/jimmunol.1102710
PMID:22504653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3378032/
Abstract

RTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum, is undergoing clinical trials. We report an analysis of cellular immune response to component Ags of RTS,S-hepatitis B surface Ag (HBs) and P. falciparum circumsporozoite (CS) protein-among Tanzanian children in a phase IIb RTS,S/AS01(E) trial. RTS,S/AS01 (E) vaccinees make stronger T cell IFN-γ, CD69, and CD25 responses to HBs peptides than do controls, indicating that RTS,S boosts pre-existing HBs responses. T cell CD69 and CD25 responses to CS and CS-specific secreted IL-2 were augmented by RTS,S vaccination. Importantly, more than 50% of peptide-induced IFN-γ(+) lymphocytes were NK cells, and the magnitude of the NK cell CD69 response to HBs peptides correlated with secreted IL-2 concentration. CD69 and CD25 expression and IL-2 secretion may represent sensitive markers of RTS,S-induced, CS-specific T cells. The potential for T cell-derived IL-2 to augment NK cell activation in RTS,S-vaccinated individuals, and the relevance of this for protection, needs to be explored further.

摘要

RTS,S/AS01 是一种针对恶性疟原虫（Plasmodium falciparum）红细胞前期的疫苗，目前正在进行临床试验。我们报告了一项针对坦桑尼亚儿童的 RTS,S/AS01(E)二期临床试验中 RTS,S-乙肝表面抗原（HBs）和疟原虫环子孢子蛋白（CS）蛋白成分的细胞免疫反应分析。与对照组相比，RTS,S/AS01(E)疫苗接种者对 HBs 肽产生更强的 T 细胞 IFN-γ、CD69 和 CD25 反应，表明 RTS,S 增强了预先存在的 HBs 反应。RTS,S 疫苗接种增强了 T 细胞 CD69 和 CD25 对 CS 和 CS 特异性分泌的 IL-2 的反应。重要的是，超过 50%的肽诱导 IFN-γ(+)淋巴细胞为 NK 细胞，并且对 HBs 肽的 NK 细胞 CD69 反应的幅度与分泌的 IL-2 浓度相关。CD69 和 CD25 的表达和 IL-2 的分泌可能是 RTS,S 诱导的 CS 特异性 T 细胞的敏感标志物。T 细胞衍生的 IL-2 增强 RTS,S 疫苗接种个体中 NK 细胞激活的潜力及其对保护的相关性需要进一步探讨。

相似文献

1
Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine.抗原特异性白细胞介素 2 分泌与坦桑尼亚儿童接种 RTS,S/AS01 疟疾疫苗后的 NK 细胞反应相关。
J Immunol. 2012 May 15;188(10):5054-62. doi: 10.4049/jimmunol.1102710. Epub 2012 Apr 13.
2
Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria.接种 RTS,S/AS01E 疫苗的儿童中的环子孢子蛋白特异性 T 细胞应答与预防恶性疟原虫临床疟疾。
PLoS One. 2011;6(10):e25786. doi: 10.1371/journal.pone.0025786. Epub 2011 Oct 6.
3
Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D).在冈比亚儿童中接种 RTS,S/AS01(E) 和 RTS,S/AS02(D) 疫苗诱导疟原虫特异性 CD4+ T 细胞和记忆 B 细胞
PLoS One. 2011 Apr 11;6(4):e18559. doi: 10.1371/journal.pone.0018559.
4
Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial.RTS,S/AS01疟疾疫苗的免疫原性及其对疫苗效力持续时间的影响：一项3期随机对照试验数据的二次分析
Lancet Infect Dis. 2015 Dec;15(12):1450-8. doi: 10.1016/S1473-3099(15)00239-X. Epub 2015 Sep 2.
5
Plasmodium falciparum-specific cellular immune responses after immunization with the RTS,S/AS02D candidate malaria vaccine in infants living in an area of high endemicity in Mozambique.在莫桑比克高疟疾流行地区，对婴儿接种RTS,S/AS02D候选疟疾疫苗后的恶性疟原虫特异性细胞免疫反应。
Infect Immun. 2009 Oct;77(10):4502-9. doi: 10.1128/IAI.00442-09. Epub 2009 Aug 3.
6
Protective immunity induced with malaria vaccine, RTS,S, is linked to Plasmodium falciparum circumsporozoite protein-specific CD4+ and CD8+ T cells producing IFN-gamma.疟疾疫苗RTS,S诱导产生的保护性免疫与产生γ干扰素的恶性疟原虫环子孢子蛋白特异性CD4+和CD8+ T细胞有关。
J Immunol. 2003 Dec 15;171(12):6961-7. doi: 10.4049/jimmunol.171.12.6961.
7
Systems analysis of protective immune responses to RTS,S malaria vaccination in humans.人类对RTS,S疟疾疫苗接种的保护性免疫反应的系统分析。
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2425-2430. doi: 10.1073/pnas.1621489114. Epub 2017 Feb 13.
8
Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children.RTS,S/AS01E 疟疾疫苗候选者在 5 至 17 个月大的肯尼亚和坦桑尼亚儿童中的安全性。
PLoS One. 2010 Nov 29;5(11):e14090. doi: 10.1371/journal.pone.0014090.
9
Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study.RTS,S/AS01 疫苗接种的非洲儿童疟疾转录相关因素：一项匹配病例对照研究。
Elife. 2022 Jan 21;11:e70393. doi: 10.7554/eLife.70393.
10
Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines: randomized, double-blind study in malaria-naïve adults.对RTS,S/AS01和RTS,S/AS02佐剂疫苗免疫反应的评估：疟疾初发成人的随机双盲研究。
Hum Vaccin Immunother. 2014;10(8):2211-9. doi: 10.4161/hv.29375.

引用本文的文献

1
Emerging Insights into Memory Natural Killer Cells and Clinical Applications.记忆自然杀伤细胞的新见解及临床应用
Viruses. 2024 Nov 7;16(11):1746. doi: 10.3390/v16111746.
2
Effect of RTS,S/AS01 vaccine booster dose on cellular immune responses in African infants and children.RTS,S/AS01疫苗加强剂量对非洲婴幼儿细胞免疫反应的影响。
NPJ Vaccines. 2024 Oct 25;9(1):200. doi: 10.1038/s41541-024-00977-y.
3
The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria.疟原虫驱动的免疫调节网络对疟疾免疫的影响。

本文引用的文献

1
Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells.用 RTS,S/AS 疫苗诱导产生的保护性免疫与产生 IL-2 和 TNF-α 的效应和中央记忆 CD4 T 细胞有关。
PLoS One. 2011;6(7):e20775. doi: 10.1371/journal.pone.0020775. Epub 2011 Jul 11.
2
T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children.根据不同方案在加纳儿童中接种的 RTS,S/AS01(E) 和 RTS,S/AS02(D) 疟疾候选疫苗的 T 细胞反应。
PLoS One. 2011 Apr 27;6(4):e18891. doi: 10.1371/journal.pone.0018891.
3
Nat Rev Immunol. 2024 Sep;24(9):637-653. doi: 10.1038/s41577-024-01041-5. Epub 2024 Jun 11.
4
Upregulation of the NKG2D Ligand ULBP2 by JC Polyomavirus Infection Promotes Immune Recognition by Natural Killer Cells.JC多瘤病毒感染导致NKG2D配体ULBP2上调，促进自然杀伤细胞的免疫识别。
J Infect Dis. 2024 Jun 14;229(6):1836-1844. doi: 10.1093/infdis/jiad424.
5
Identification and Characterization of Epithelial Cell-Derived Dense Bodies Produced upon Cytomegalovirus Infection.巨细胞病毒感染后产生的上皮细胞源性致密体的鉴定与特征分析。
Vaccines (Basel). 2022 Aug 12;10(8):1308. doi: 10.3390/vaccines10081308.
6
CMV-associated T cell and NK cell terminal differentiation does not affect immunogenicity of ChAdOx1 vaccination.CMV 相关的 T 细胞和 NK 细胞终末分化不影响 ChAdOx1 疫苗的免疫原性。
JCI Insight. 2022 Mar 22;7(6):e154187. doi: 10.1172/jci.insight.154187.
7
Malaria Vaccines and Vaccine Adjuvants.疟疾疫苗与疫苗佐剂
Vaccines (Basel). 2021 Sep 24;9(10):1072. doi: 10.3390/vaccines9101072.
8
Specific human cytomegalovirus signature detected in NK cell metabolic changes post vaccination.接种疫苗后自然杀伤细胞代谢变化中检测到的特定人类巨细胞病毒特征。
NPJ Vaccines. 2021 Sep 28;6(1):117. doi: 10.1038/s41541-021-00381-w.
9
Durable natural killer cell responses after heterologous two-dose Ebola vaccination.异源两剂埃博拉疫苗接种后的持久自然杀伤细胞反应。
NPJ Vaccines. 2021 Jan 29;6(1):19. doi: 10.1038/s41541-021-00280-0.
10
Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV).解析适应性自然杀伤 (NK) 细胞和巨细胞病毒 (CMV) 的免疫学现象。
Int J Mol Sci. 2020 Nov 23;21(22):8864. doi: 10.3390/ijms21228864.
Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D).
在冈比亚儿童中接种 RTS,S/AS01(E) 和 RTS,S/AS02(D) 疫苗诱导疟原虫特异性 CD4+ T 细胞和记忆 B 细胞
PLoS One. 2011 Apr 11;6(4):e18559. doi: 10.1371/journal.pone.0018559.
4
Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial.肯尼亚和坦桑尼亚 5-17 月龄儿童中 RTS,S/AS01E 疟疾疫苗的有效性及抗环子孢子蛋白抗体滴度和保护作用的探索性分析：一项随机对照试验。
Lancet Infect Dis. 2011 Feb;11(2):102-9. doi: 10.1016/S1473-3099(10)70262-0. Epub 2011 Jan 13.
5
Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children.RTS,S/AS01E 疟疾疫苗候选者在 5 至 17 个月大的肯尼亚和坦桑尼亚儿童中的安全性。
PLoS One. 2010 Nov 29;5(11):e14090. doi: 10.1371/journal.pone.0014090.
6
From vaccines to memory and back.从疫苗到记忆，再回到疫苗。
Immunity. 2010 Oct 29;33(4):451-63. doi: 10.1016/j.immuni.2010.10.008.
7
NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination.NK 细胞作为获得性免疫反应的效应细胞：接种疫苗后效应 CD4+T 细胞依赖性激活 NK 细胞。
J Immunol. 2010 Sep 1;185(5):2808-18. doi: 10.4049/jimmunol.1000844. Epub 2010 Aug 2.
8
The RTS,S malaria vaccine.RTS,S 疟疾疫苗。
Vaccine. 2010 Jul 12;28(31):4880-94. doi: 10.1016/j.vaccine.2010.05.033. Epub 2010 May 27.
9
Cross-talk between T cells and NK cells generates rapid effector responses to Plasmodium falciparum-infected erythrocytes.T 细胞和自然杀伤细胞之间的串扰可迅速产生针对恶性疟原虫感染红细胞的效应反应。
J Immunol. 2010 Jun 1;184(11):6043-52. doi: 10.4049/jimmunol.1000106. Epub 2010 Apr 28.
10
Malaria in Africa: progress and prospects in the decade since the Abuja Declaration.非洲的疟疾：自《阿布贾宣言》发布以来十年的进展与前景
Lancet. 2010 Jul 10;376(9735):137-9. doi: 10.1016/S0140-6736(10)60577-6. Epub 2010 Apr 22.