Bataille D, Peillon F, Besson J, Rosselin G
C R Seances Acad Sci D. 1979 May 7;288(17):1315-7.
Receptors for the Vasoactive Intestinal Peptide (VIP) were characterized in particles enriched in plasma membranes obtained from a human prolactin-secreting pituiatry tumor. Native VIP inhibited competitively the binding of 125I-VIP to the particles and stimulated cyclic AMP production; both these effects were observed at concentrations of VIP as low as 10(-11)-10(-10) M, which are compatible with VIP concentrations in the hypothalamopituitary portal blood.
在从人催乳素分泌型垂体肿瘤中获得的富含质膜的微粒中对血管活性肠肽(VIP)受体进行了特性鉴定。天然VIP竞争性抑制125I-VIP与微粒的结合,并刺激环磷酸腺苷的产生;在低至10^(-11)-10^(-10) M的VIP浓度下就观察到了这两种效应,这与下丘脑-垂体门脉血中的VIP浓度相符。