Animal Health and Veterinary Laboratory Agency, Pentland Science Park, Bush Loan, Penicuik EH26 0PZ, Midlothian, UK.
Folia Neuropathol. 2012;50(1):13-9.
Prion-like transmission of protein aggregates or amyloid in several neurodegenerative diseases, such as Parkinson's disease, Huntington's disease and Alzheimer's disease, in addition to the transmissible spongiform encephalopathies (or prion diseases), has been proposed recently. This is a controversial idea and, in this paper, we consider what we mean by a "prion", and by "amyloid", and present some biochemical investigations of cerebral prion amyloidosis in mice.
朊病毒样蛋白聚集物或淀粉样蛋白在几种神经退行性疾病中的传递，如帕金森病、亨廷顿病和阿尔茨海默病，除了传染性海绵状脑病（或朊病毒病）之外，最近也被提出。这是一个有争议的观点，在本文中，我们考虑了“朊病毒”和“淀粉样蛋白”的含义，并对小鼠脑中朊病毒淀粉样变性进行了一些生化研究。
