Aguilar-Calvo Patricia, García Consolación, Espinosa Juan Carlos, Andreoletti Olivier, Torres Juan María
Centro de Investigación en Sanidad Animal (CISA-INIA), 28130 Valdeolmos, Madrid, Spain.
INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, École Nationale Vétérinaire de Toulouse, 23 chemin des Capelles, 31076 Toulouse Cedex, France.
Virus Res. 2015 Sep 2;207:82-93. doi: 10.1016/j.virusres.2014.11.026. Epub 2014 Nov 29.
Transmissible spongiform encephalopaties (TSEs) are fatal neurodegenerative diseases characterized by the aggregation and accumulation of the misfolded prion protein in the brain. Other proteins such as β-amyloid, tau or Serum Amyloid-A (SAA) seem to share with prions some aspects of their pathogenic mechanism; causing a variety of so called prion-like diseases in humans and/or animals such as Alzheimer's, Parkinson's, Huntington's, Type II diabetes mellitus or amyloidosis. The question remains whether these misfolding proteins have the ability to self-propagate and transmit in a similar manner to prions. In this review, we describe the prion and prion-like diseases affecting animals as well as the recent findings suggesting the prion-like transmissibility of certain non-prion proteins.
传染性海绵状脑病（TSEs）是致命的神经退行性疾病，其特征是错误折叠的朊病毒蛋白在大脑中聚集和积累。其他蛋白质，如β-淀粉样蛋白、tau蛋白或血清淀粉样蛋白A（SAA），似乎在致病机制的某些方面与朊病毒有共同之处；在人类和/或动物中引发各种所谓的朊病毒样疾病，如阿尔茨海默病、帕金森病、亨廷顿病、II型糖尿病或淀粉样变性。问题仍然是这些错误折叠的蛋白质是否具有以与朊病毒类似的方式自我传播和传播的能力。在这篇综述中，我们描述了影响动物的朊病毒和朊病毒样疾病，以及表明某些非朊病毒蛋白具有朊病毒样传播性的最新发现。
