Bakirtaş Arzu, Arga Mustafa, Eğrıtaş Odül, Topal Erdem, Sari Sinan, Poyraz Aylar, Dalgiç Buket, Demırsoy Mehmet Sadık, Türktaş Ipek
Gazi University, Faculty of Medicine, Department of Pediatric Allergy and Asthma, Ankara, Turkey.
Turk J Gastroenterol. 2012 Feb;23(1):1-7.
BACKGROUND/AIMS: Eosinophilic esophagitis is a rare allergic disease of the esophagus with no published data in Turkish children.
This is an observational study of children diagnosed as eosinophilic esophagitis in our hospital between February 2009 and January 2011. We retrospectively analyzed the clinical features, allergic work-up, endoscopic and histological findings, and response to treatment.
We followed seven patients in this period with a histopathologic diagnosis of eosinophilic esophagitis. The mean age at diagnosis was 5.05±2.97 years (range: 1-9 years), and four of them were male. The most frequent symptom was gastroesophageal reflux disease-like symptoms (vomiting, regurgitation, and heartburn) (42.9%). Peripheral eosinophilia and high serum total IgE levels were found in four patients (57.2%). Sensitization to food (71.4%) was more frequent than that of aeroallergens (28.6%). Endoscopic findings suggestive of eosinophilic esophagitis were present in four patients (57.2%). Comorbid allergic disease was present in five patients (71.4%). All patients were treated by elimination diet (85.7%) and/or inhaled corticosteroid treatment (71.4%). The mean follow-up period was 12.4±6.1 months (range: 6-24 months). All but one patient showed complete clinical response to their treatment. No significant side effect was observed during the follow-up period.
Eosinophilic esophagitis is a rare gastrointestinal allergic disorder frequently comorbid with other allergic diseases and with different manifestations and response profiles to treatment modalities.
背景/目的：嗜酸性粒细胞性食管炎是一种罕见的食管过敏性疾病，在土耳其儿童中尚无相关数据发表。
这是一项对2009年2月至2011年1月期间在我院被诊断为嗜酸性粒细胞性食管炎的儿童进行的观察性研究。我们回顾性分析了临床特征、过敏检查、内镜和组织学检查结果以及治疗反应。
在此期间，我们对7例经组织病理学诊断为嗜酸性粒细胞性食管炎的患者进行了随访。诊断时的平均年龄为5.05±2.97岁（范围：1 - 9岁），其中4例为男性。最常见的症状是胃食管反流病样症状（呕吐、反流和烧心）（42.9%）。4例患者（57.2%）外周血嗜酸性粒细胞增多和血清总IgE水平升高。对食物过敏（71.4%）比对气传变应原过敏（28.6%）更常见。4例患者（57.2%）有提示嗜酸性粒细胞性食管炎 的内镜检查结果。5例患者（71.4%）存在合并过敏性疾病。所有患者均接受了排除饮食治疗（85.7%）和/或吸入性糖皮质激素治疗（71.4%）。平均随访期为12.4±6.1个月（范围：6 - 24个月）。除1例患者外，所有患者对治疗均表现出完全临床反应。随访期间未观察到明显副作用。
嗜酸性粒细胞性食管炎是一种罕见的胃肠道过敏性疾病，常与其他过敏性疾病合并存在，且对治疗方式有不同的表现和反应特征。
