Division of Allergy, Immunology, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Semin Immunopathol. 2012 Sep;34(5):715-31. doi: 10.1007/s00281-012-0324-x. Epub 2012 Jul 29.
Eosinophilic gastrointestinal diseases are a group of chronic diseases characterized by a range of symptoms caused by eosinophilic inflammation of various parts of the gastrointestinal tract. Other causes for eosinophilia need to be ruled out prior to making the diagnosis of EGIDs. The most common form of EGID is eosinophilic esophagitis (EoE), an antigen-driven disease that afflicts children and adults and has been identified across the world. Histological features include dense eosinophilia of the esophageal mucosa, eosinophil degranulation, eosinophil microabscess formation, and other features of epithelial inflammation including basal zone hyperplasia and rete pege elongation. Treatments include dietary exclusions and topical corticosteroids.
嗜酸性粒细胞性胃肠道疾病是一组以胃肠道各部位嗜酸性粒细胞炎症引起的多种症状为特征的慢性疾病。在做出 EGIDs 的诊断之前，需要排除其他引起嗜酸性粒细胞增多的原因。最常见的 EGID 形式是嗜酸性食管炎 (EoE)，这是一种抗原驱动的疾病，影响儿童和成人，在世界各地都有发现。组织学特征包括食管黏膜嗜酸性粒细胞密集、嗜酸性粒细胞脱颗粒、嗜酸性粒细胞微脓肿形成以及上皮炎症的其他特征，包括基底带增生和网织状延长。治疗包括饮食排除和局部皮质类固醇。
