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血清素能药物对氟哌啶醇诱导的僵住症的影响。

The effect of serotonergic agents on haloperidol-induced catalepsy.

作者信息

Hicks P B

机构信息

Department of Psychiatry, Scott and White Memorial Hospital, Temple, Texas.

出版信息

Life Sci. 1990;47(18):1609-15. doi: 10.1016/0024-3205(90)90365-x.

DOI:10.1016/0024-3205(90)90365-x
PMID:2250574
Abstract

The effect of various classes of serotonergic agents on haloperidol-induced catalepsy was evaluated in male Sprague-Dawley rats. The 5-HT-1A agonists buspirone, ipsapirone and 8-OH-DPAT all potently reversed catalepsy. The mixed 5-HT-1A and 5-HT-1B agonist RU 24969 reversed catalepsy only at the highest dose tested. The non-selective 5-HT-1 antagonist (l)-propranolol did not affect catalepsy. The 5-HT-2 agonist DOI and 5-HT-2 antagonist mesulergine both reversed catalepsy. ICS 205-930 (5-HT-3 antagonist) reversed catalepsy at low doses only. Another 5-HT-3 antagonist, GR 38032F, had no effect on catalepsy. These studies suggest that 5-HT-1A and 5-HT-2 receptor sites are important in the serotonergic modulation of haloperidol-induced catalepsy.

摘要

在雄性斯普拉格-道利大鼠中评估了各类血清素能药物对氟哌啶醇诱导的僵住症的影响。5-HT-1A激动剂丁螺环酮、伊沙匹隆和8-OH-DPAT均能有效逆转僵住症。5-HT-1A和5-HT-1B混合激动剂RU 24969仅在测试的最高剂量下能逆转僵住症。非选择性5-HT-1拮抗剂（l）-普萘洛尔不影响僵住症。5-HT-2激动剂DOI和5-HT-2拮抗剂美舒麦角均能逆转僵住症。ICS 205-930（5-HT-3拮抗剂）仅在低剂量时能逆转僵住症。另一种5-HT-3拮抗剂GR 38032F对僵住症无影响。这些研究表明，5-HT-1A和5-HT-2受体位点在血清素能调节氟哌啶醇诱导的僵住症中很重要。

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