Silva S R, Futuro-Neto H A, Pires J G
Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, Brasil.
Braz J Med Biol Res. 1990;23(9):869-71.
Neuroleptics such as chlorpromazine and haloperidol are capable of inducing catalepsy in rodents. Non-selective 5-hydroxytryptamine (5-HT) antagonists such as methysergide reduce the cataleptic effect of haloperidol. The present study was designed to evaluate the participation of 5-HT-1A receptors in chlorpromazine-induced catalepsy in mice. Pindolol and buspirone, two putative 5-HT-1A receptor ligands, were used. Pretreatment with these drugs reduced the cataleptic effect of chlorpromazine. Clomipramine, a 5-HT neuronal uptake blocker, reversed the inhibitory effect of buspirone. Pretreatment with clomipramine alone caused a potentiation of neuroleptic-induced catalepsy. These results suggest that central 5-HT-1A receptors play an important role in neuroleptic-induced catalepsy in mice.
氯丙嗪和氟哌啶醇等抗精神病药物能够在啮齿动物中诱发僵住症。非选择性5-羟色胺（5-HT）拮抗剂如麦角酰二乙胺可降低氟哌啶醇的僵住症效应。本研究旨在评估5-HT-1A受体在氯丙嗪诱发小鼠僵住症中的作用。使用了两种假定的5-HT-1A受体配体——吲哚洛尔和丁螺环酮。用这些药物预处理可降低氯丙嗪的僵住症效应。5-HT神经元摄取阻滞剂氯米帕明可逆转丁螺环酮的抑制作用。单独用氯米帕明预处理会增强抗精神病药物诱发的僵住症。这些结果表明，中枢5-HT-1A受体在小鼠抗精神病药物诱发的僵住症中起重要作用。
