基于尿糖自我监测的 2 型糖尿病患者门诊治疗和教学计划，可改善糖化血红蛋白（HbA1c）并稳定体重减轻 2 年。

Improvement of HbA(1c) and stable weight loss 2 years after an outpatient treatment and teaching program for patients with type 2 diabetes without insulin therapy based on urine glucose self-monitoring.

机构信息

University Hospital of Jena, Department of Internal Medicine III, Jena, Germany.

出版信息

Int J Gen Med. 2012;5:241-7. doi: 10.2147/IJGM.S28505. Epub 2012 Mar 13.

DOI:10.2147/IJGM.S28505

PMID:22505822

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3325012/

Abstract

OBJECTIVE

Long-term outcomes after participation in a structured diabetes treatment and teaching program (DTTP) for patients with diabetes without insulin use, primarily based upon postprandial urine glucose self-monitoring (UGSM).

METHODS

A total of 126 patients took part in the DTTP in a university outpatient department in 2004-2005. We re-evaluated 119 (94.4%) at baseline and at 6 months, 12 months, and 24 months. Hemoglobin A(1c) (HbA(1c)) was DCCT adjusted.

RESULTS

HbA(1c) decreased significantly 6 months after education from 7.33% (±1.59%) to 6.89% (±0.98%; P = 0.001 versus baseline) and was maintained for up to 12 months (7.02% ± 1.07%; P = 0.017 versus baseline) as well as up to 24 months (6.96% ± 1.06%; P = 0.005 versus baseline). Weight decreased from 92.5 kg at baseline to 90.3 kg at 24 months (P = 0.014). A total of 36.5% of patients not on insulin therapy preferred UGSM, whereas 23.5% preferred blood glucose monitoring, at 24 months. Glucose control was similar in both groups at 24 months (HbA(1c) UGSM 7.03 versus blood glucose monitoring 6.97%; P = 0.807).

CONCLUSION

Participation in the DTTP resulted in long-term behavior modification. HbA(1c) of patients without insulin met the target 24 months after the DTTP, irrespective of the type of glucose self-monitoring.

摘要

目的

参与基于餐后尿糖自我监测（UGSM）的糖尿病结构化治疗和教学计划（DTTP）的糖尿病患者，其胰岛素治疗方案不发生改变，主要评估长期治疗结局。

方法

2004-2005 年，我们在一所大学的门诊部共招募了 126 名接受 DTTP 的患者。我们在基线时、治疗 6 个月、12 个月和 24 个月时对 119 名患者（94.4%）进行了重新评估。我们采用 DCCT 校正糖化血红蛋白（HbA(1c)）。

结果

经过 6 个月的教育，HbA(1c)从基线时的 7.33%（±1.59%）显著下降至 6.89%（±0.98%；P=0.001 与基线相比），并在 12 个月时（7.02%±1.07%；P=0.017 与基线相比）和 24 个月时（6.96%±1.06%；P=0.005 与基线相比）得以维持。体重从基线时的 92.5kg 下降至 24 个月时的 90.3kg（P=0.014）。在 24 个月时，共有 36.5%未接受胰岛素治疗的患者更喜欢 UGSM，而 23.5%更喜欢血糖监测。两组患者在 24 个月时的血糖控制情况相似（UGSM 组 HbA(1c)为 7.03%，血糖监测组为 6.97%；P=0.807）。