Department of Neurology, University at Buffalo, Buffalo, NY 14214, USA.
J Clin Sleep Med. 2012 Apr 15;8(2):187-9. doi: 10.5664/jcsm.1776.
Insomnia related to nighttime awakenings is known to be more prevalent in women than men. Three cases are presented here of late premenopausal women experiencing frequent nighttime awakenings that responded well to bedtime treatment with gabapentin. In one case, what started as isolated nighttime awakenings slowly progressed to awakenings accompanied by typical menopausal night sweats. This led to the theory that the initial isolated nighttime awakenings in this patient may have been secondary to a menopausal etiology related to low serum estradiol levels. In the subsequent 2 cases, early follicular phase serum estradiol was confirmed to be low. It is theorized that isolated nighttime awakenings in some premenopausal women may be caused by low serum estradiol, triggering events physiologically related to menopausal night sweats. Further research is needed to determine if low early follicular phase serum estradiol is associated with nighttime awakenings in premenopausal women not experiencing night sweats.
与夜间觉醒相关的失眠症在女性中比男性更为常见。这里介绍了 3 例即将进入绝经期的女性，她们经常在夜间醒来，在睡前服用加巴喷丁后反应良好。在 1 例中，最初孤立的夜间觉醒逐渐发展为伴有典型更年期盗汗的觉醒。这就提出了这样一种理论，即该患者最初孤立的夜间觉醒可能是由与血清雌二醇水平低相关的绝经病因引起的。在后 2 例中，早期卵泡期血清雌二醇水平确认较低。据推测，一些绝经前妇女的孤立性夜间觉醒可能是由血清雌二醇水平低引起的，引发与更年期盗汗生理性相关的事件。需要进一步研究以确定在不经历盗汗的绝经前妇女中，早期卵泡期血清雌二醇水平低是否与夜间觉醒有关。
