Gill Richdeep S, Karmali Shahzeer, Nagandran Jeevan, Frazier Howard O, Sherman Vadim
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
J Clin Med Res. 2012 Apr;4(2):127-9. doi: 10.4021/jocmr814w. Epub 2012 Mar 23.
Morbid obesity remains a potential relative contraindication for cardiac transplantation. Hence, a select population of morbidly obese patients with end-stage heart failure may require a ventricular assist device (VAD) as a bridge to transplantation to afford them time to lose sufficient weight and thus decrease there mortality rate after transplantation. Unfortunately, obtaining suitable weight loss via dietary or exercise regimens is limited by the cardiac limitations of the patients. We report on a new procedure of combining ventricular assist device placement with adjustable gastric band (VAD-BAND) placement to facilitate sufficient weight loss for cardiac transplantation.
We report on our experience of 2 morbidly obese (BMI 46.6, BMI 43.7) patients with severe non-ischemic cardiomyopathy who underwent a VAD-BAND placement for treatment of morbid obesity and potential future cardiac transplantation.
Patient 1 was a 24-year-old male with a body mass index (BMI) of 46.6 admitted in cardiogenic shock with severe non-ischemic cardiomyopathy (New York Functional Class IV, Left Ventricular Ejection Fraction 15.3%) who underwent the VAD-BAND procedure. At 11 months outpatient follow-up the patient had clinically improved with a BMI of 34.2. Patient 2 was a 36-year-old male with a body mass index of 43.7 admitted in cardiogenic shock with severe non-ischemic cardiomyopathy (New York Functional Class IV, Left Ventricular Ejection Fraction 17.1%) who underwent placement of a VAD-BAND. At 4 months post-operation, the patient was stalwart clinically with a BMI of 34.8. Both patients are now under consideration for cardiac transplantation.
In conclusion, concurrent placement of a VAD-BAND is a safe and viable option for morbidly obese patients with end-stage heart disease. Further research is needed to define indications and future clinical practice.
Gastric band; Ventricular assist device; Morbid obesity; Heart failure; Transplantation; Weight loss.
病态肥胖仍然是心脏移植潜在的相对禁忌证。因此,部分患有终末期心力衰竭的病态肥胖患者可能需要心室辅助装置(VAD)作为移植桥梁,以便有时间减轻足够体重,从而降低移植后的死亡率。不幸的是,通过饮食或运动方案实现适当体重减轻受到患者心脏功能限制。我们报告一种将心室辅助装置植入与可调胃束带(VAD-BAND)植入相结合的新手术,以促进为心脏移植进行充分的体重减轻。
我们报告了2例病态肥胖(BMI分别为46.6和43.7)且患有严重非缺血性心肌病患者的经验,他们接受了VAD-BAND植入手术,用于治疗病态肥胖及未来可能的心脏移植。
患者1是一名24岁男性,体重指数(BMI)为46.6,因严重非缺血性心肌病导致心源性休克入院(纽约心功能分级IV级,左心室射血分数15.3%),接受了VAD-BAND手术。门诊随访11个月时,患者临床症状改善,BMI为34.2。患者2是一名36岁男性,体重指数为43.7,因严重非缺血性心肌病导致心源性休克入院(纽约心功能分级IV级,左心室射血分数17.1%),接受了VAD-BAND植入。术后4个月,患者临床状况良好,BMI为34.8。两名患者目前均在考虑进行心脏移植。
总之,对于患有终末期心脏病的病态肥胖患者,同时植入VAD-BAND是一种安全可行的选择。需要进一步研究来明确适应证及未来的临床实践。
胃束带;心室辅助装置;病态肥胖;心力衰竭;移植;体重减轻。