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Relationship between lipoprotein(a) concentrations and intima-media thickness: a healthy population study.脂蛋白(a)浓度与内中膜厚度的关系：一项健康人群研究。
Eur J Prev Cardiol. 2012 Dec;19(6):1290-5. doi: 10.1177/1741826711423216. Epub 2011 Sep 13.
2
Serum lipoprotein (a) levels in patients with arterial hypertension.动脉高血压患者的血清脂蛋白（a）水平
Rev Med Chir Soc Med Nat Iasi. 2010 Jul-Sep;114(3):798-802.
3
Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk.LPAL2、LPA 和 PLG 中的遗传变异可预测血浆脂蛋白(a)水平和颈动脉疾病风险。
Stroke. 2011 Jan;42(1):2-9. doi: 10.1161/STROKEAHA.110.591230. Epub 2010 Dec 2.
4
Lipoprotein(a) as a cardiovascular risk factor: current status.脂蛋白(a)作为心血管风险因素：现状。
Eur Heart J. 2010 Dec;31(23):2844-53. doi: 10.1093/eurheartj/ehq386. Epub 2010 Oct 21.
5
Genetic variants associated with Lp(a) lipoprotein level and coronary disease.与脂蛋白(a)水平和冠心病相关的遗传变异。
N Engl J Med. 2009 Dec 24;361(26):2518-28. doi: 10.1056/NEJMoa0902604.
6
Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.脂蛋白(a)浓度与冠心病、中风及非血管性死亡风险
JAMA. 2009 Jul 22;302(4):412-23. doi: 10.1001/jama.2009.1063.
7
The value of lipoprotein (a), homocysteine, and Doppler of carotid and femoral arteries in assessment of atherosclerosis in asymptomatic cardiovascular risk patients.脂蛋白 (a)、同型半胱氨酸、颈动脉和股动脉多普勒在无症状心血管风险患者动脉粥样硬化评估中的价值。
J Cardiol. 2008 Dec;52(3):202-11. doi: 10.1016/j.jjcc.2008.08.001. Epub 2008 Sep 18.
8
Impact of markedly elevated serum lipoprotein(a) levels (> or = 100 mg/dL) on the risk of coronary heart disease.血清脂蛋白(a)水平显著升高（≥100mg/dL）对冠心病风险的影响。
Metabolism. 2007 Sep;56(9):1187-91. doi: 10.1016/j.metabol.2007.04.015.
9
Fish intake and LPA 93C>T polymorphism: gene-environment interaction in modulating lipoprotein (a) concentrations.鱼类摄入量与脂蛋白A 93C>T多态性：调节脂蛋白(a)浓度中的基因-环境相互作用。
Atherosclerosis. 2007 Dec;195(2):e147-54. doi: 10.1016/j.atherosclerosis.2007.05.020. Epub 2007 Jul 2.
10
Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study.氧化磷脂、脂蛋白（a）、脂蛋白相关磷脂酶A2活性与10年心血管结局：布伦内克研究的前瞻性结果
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低脂蛋白(a)水平无症状受试者的颈动脉内膜中层厚度

Carotid Intima-Media Thickness in Asymptomatic Subjects With Low Lipoprotein(a) Levels.

作者信息

Kotani Kazuhiko, Sakane Naoki

机构信息

Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

出版信息

J Clin Med Res. 2012 Apr;4(2):130-4. doi: 10.4021/jocmr849w. Epub 2012 Mar 23.

DOI:10.4021/jocmr849w
PMID:22505987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3320123/
Abstract

BACKGROUND

Elevated and extreme circulating levels of lipoprotein(a) (Lp(a)) are considered to be an atherosclerotic risk factor, although additional studies on the low levels of Lp(a) are necessary to provide confirmation. The carotid intima-media thickness (CIMT) is known as a surrogate index of atherosclerosis. The aim of the present study was to investigate the correlation between the serum Lp(a) and CIMT in asymptomatic subjects with a relatively low Lp(a) level.

METHODS

The study included 65 asymptomatic female Japanese subjects (mean age: 60 years) with a serum Lp(a) level < 30 mg/dL. Clinical data including the serum Lp(a) and CIMT were measured, and their correlations were examined.

RESULTS

The median Lp(a) level was 18.6 mg/dL and the mean CIMT level was 0.8 mm. There was a significant and inverse correlation between the CIMT and Lp(a) (r = - 0.24, P ≤ 0.05), in addition to a significant and positive correlation between the CIMT and subject age and systolic blood pressure. A stepwise multiple linear regression analysis identified the Lp(a) to be correlated independently, significantly and inversely with the CIMT.

CONCLUSIONS

The Lp(a) levels were inversely correlated with the CIMT in this population, suggesting that subjects with a low Lp(a) level may have a predisposition to carotid atherosclerosis. This finding was preliminary and should be investigated further in larger studies and in additional settings.

KEYWORDS

Lp(a); Carotid artery; IMT; Atherosclerosis.

摘要

背景

脂蛋白(a)[Lp(a)]的循环水平升高和极高被认为是动脉粥样硬化的危险因素，不过还需要对Lp(a)低水平进行更多研究以加以证实。颈动脉内膜中层厚度（CIMT）是已知的动脉粥样硬化替代指标。本研究的目的是调查Lp(a)水平相对较低的无症状受试者血清Lp(a)与CIMT之间的相关性。

方法

本研究纳入了65名无症状日本女性受试者（平均年龄：60岁），其血清Lp(a)水平<30mg/dL。测量包括血清Lp(a)和CIMT在内的临床数据，并检查它们之间的相关性。

结果

Lp(a)水平中位数为18.6mg/dL，CIMT平均水平为0.8mm。CIMT与Lp(a)之间存在显著负相关（r=-0.24，P≤0.05），此外，CIMT与受试者年龄和收缩压之间存在显著正相关。逐步多元线性回归分析确定Lp(a)与CIMT独立、显著且呈负相关。

结论

该人群中Lp(a)水平与CIMT呈负相关，这表明Lp(a)水平低的受试者可能易患颈动脉粥样硬化。这一发现是初步的，应在更大规模的研究和更多环境中进一步调查。

关键词

Lp(a)；颈动脉；内膜中层厚度；动脉粥样硬化