Kotani Kazuhiko, Shimohiro Hisashi, Adachi Seiji, Sakane Naoki
Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan.
Gerontology. 2008;54(6):361-4. doi: 10.1159/000145541. Epub 2008 Jul 12.
Lipoprotein(a) [Lp(a)] or metabolic syndrome (MS) is individually considered an atherosclerotic factor. Serum Lp(a) may reportedly show the additive effects on atherosclerosis under certain particular pathologies. We do not know the association between serum Lp(a) and carotid artery intima-media thickness (CIMT) with relation to MS in older people.
The present study aims at investigating the relationship between Lp(a) and CIMT levels in relation to MS among older subjects.
We studied 182 Japanese subjects of >or=60 years (mean 72.5 years), free of cardiovascular/cerebrovascular disease. MS was based on the NCEP-ATPIII criteria with a minor modification for Japanese. The CIMT was ultrasonographically measured.
The CIMT levels were significantly greater in the MS group (n = 60, 1.03 +/- 0.22 mm) than the non-MS group (n = 122, 0.96 +/- 0.22 mm). Multivariate analysis, using Lp(a) levels or the product term for interaction between Lp(a) and MS, showed that age significantly and independently correlated to CIMT, along with male gender.
Even when Lp(a) and MS were simultaneously considered, age was the best determinant of CIMT in this population. The mechanism of our results including weak additive effects of Lp(a) and MS among older subjects may be partly throughout aging.
脂蛋白(a)[Lp(a)]或代谢综合征(MS)各自被视为动脉粥样硬化因子。据报道，血清Lp(a)在某些特定病理情况下可能对动脉粥样硬化有累加效应。我们尚不清楚老年人血清Lp(a)和颈动脉内膜中层厚度(CIMT)与MS之间的关联。
本研究旨在调查老年受试者中Lp(a)与CIMT水平和MS之间的关系。
我们研究了182名年龄≥60岁（平均72.5岁）、无心血管/脑血管疾病的日本受试者。MS依据NCEP-ATPIII标准并针对日本人进行了轻微修改来判定。通过超声测量CIMT。
MS组（n = 60，1.03±0.22 mm）的CIMT水平显著高于非MS组（n = 122，0.96±0.22 mm）。使用Lp(a)水平或Lp(a)与MS之间交互作用的乘积项进行多变量分析显示，年龄以及男性性别与CIMT显著且独立相关。
即使同时考虑Lp(a)和MS，年龄仍是该人群中CIMT的最佳决定因素。我们研究结果的机制，包括老年受试者中Lp(a)和MS的微弱累加效应，可能部分贯穿于衰老过程。
