Nemere I, Norman A W
Department of Biochemistry, University of California, Riverside.
Miner Electrolyte Metab. 1990;16(2-3):109-14.
Within the past 5 years it has become apparent that the biological actions of the seco-steroid 1,25-dihydroxyvitamin D3 are more complex than previously realized. Many cell types respond in both a classical genomic manner, as well as in a nongenomic fashion to 1,25(OH)2D3. In intestine, the presumptive nongenomic effects of the seco-steroid result in transcaltachia, the rapid, hormonal stimulation of calcium transport. To better understand nongenomic points of regulation in the intestine, studies were undertaken to identify the subcellular components of the 1,25(OH)2D3-stimulated calcium transport pathway. This research has revealed the existence of a vesicular transport mechanism, an involvement of microtubules, and microtubule-associated calbindin-D28K.
在过去5年里，很明显，甾体类激素1,25 - 二羟基维生素D3的生物学作用比之前认识到的更为复杂。许多细胞类型对1,25(OH)2D3既呈现经典的基因组反应方式，也有非基因组反应方式。在肠道中，这种甾体类激素推测的非基因组效应导致了快速钙转运，即对钙转运的快速激素刺激。为了更好地理解肠道中非基因组调控点，开展了相关研究以确定1,25(OH)2D3刺激的钙转运途径的亚细胞成分。这项研究揭示了一种囊泡运输机制的存在、微管的参与以及与微管相关的钙结合蛋白-D28K。
