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维生素D状态与脊柱手术结果。

Vitamin d status and spine surgery outcomes.

作者信息

Rodriguez William J, Gromelski Jason

机构信息

Nola Physical Therapy, 2 West 45th Street, Suite 208, New York, NY 10036, USA.

出版信息

ISRN Orthop. 2013 Apr 11;2013:471695. doi: 10.1155/2013/471695. eCollection 2013.

Abstract

There is a high prevalence of hypovitaminosis D in patients with back pain regardless of whether or not they require surgical intervention. Furthermore, the risk of hypovitaminosis D is not limited to individuals with traditional clinical risk factors. Vitamin D plays an essential role in bone formation, maintenance, and remodeling, as well as muscle function. Published data indicate that hypovitaminosis D could adversely affect bone formation and muscle function in multiple ways. The literature contains numerous reports of myopathy and/or musculoskeletal pain associated with hypovitaminosis D. In terms of spinal fusion outcomes, a patient may have a significant decrease in pain and the presence of de novo bone on an X-ray, yet their functional ability may remain severely limited. Hypovitaminosis D may be a contributing factor to the persistent postoperative pain experienced by these patients. Indeed, hypovitaminosis D is not asymptomatic, and symptoms can manifest themselves independent of the musculoskeletal pathological changes associated with conditions like osteomalacia. It appears that vitamin D status is routinely overlooked, and there is a need to raise awareness about its importance among all healthcare practitioners who treat spine patients.

摘要

无论是否需要手术干预,背痛患者中维生素D缺乏症的患病率都很高。此外,维生素D缺乏症的风险并不局限于具有传统临床风险因素的个体。维生素D在骨骼形成、维持和重塑以及肌肉功能方面起着至关重要的作用。已发表的数据表明,维生素D缺乏症可能会以多种方式对骨骼形成和肌肉功能产生不利影响。文献中有许多关于与维生素D缺乏症相关的肌病和/或肌肉骨骼疼痛的报道。就脊柱融合手术的结果而言,患者的疼痛可能会显著减轻,X线片上也会出现新生骨,但他们的功能能力可能仍然严重受限。维生素D缺乏症可能是这些患者术后持续疼痛的一个促成因素。事实上,维生素D缺乏症并非没有症状,其症状可能独立于与骨软化症等疾病相关的肌肉骨骼病理变化而出现。看来维生素D状态经常被忽视,有必要提高所有治疗脊柱疾病患者的医护人员对其重要性的认识。

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