Fazzi E, Bianchini L, Ometto A, Piazza F, Rondini G, Lanzi G
Divisione e Cattedra di Neuropsichiatria Infantile, IRCCS Fondazione C. Mondino Università di Pavia.
Minerva Pediatr. 1990 Jun;42(6):219-25.
One hundred twenty-seven children born between September 1st 1980 and August 31st 1985 weighing less than or equal to 1500 g at birth and submitted to intensive neonatal care were followed-up to the age of 12-36 months of corrected age with a follow-up program to assess their neuromotor and cognitive development. The incidence of cerebral palsy (CP) in the population in question was 15.7% at 12 and 24 months and 14.6% at 36 months. A peak CP rate was observed among those born in 1982 with a steady decline in the number of CP cases among those born in the last years of this study. The group of children with a birth weight of 1001-1500 g (VLBWI) was more heavily affected by CP than those whose weight was less than or equal to 1000 g (ELBWI). Statistical analysis revealed a significant correlation between neuromotor development and the following factors relative to the perinatal period: type of birth, sex, respiratory distress requiring assisted ventilation, acidosis, ultrasound, neurological examination at the 40th week of gestational age.
对1980年9月1日至1985年8月31日出生、出生时体重小于或等于1500克且接受新生儿重症监护的127名儿童进行随访,随访至矫正年龄12至36个月,通过随访计划评估其神经运动和认知发育情况。该人群中脑瘫(CP)的发病率在12个月和24个月时为15.7%,在36个月时为14.6%。观察到1982年出生的儿童中脑瘫发生率最高,在本研究最后几年出生的儿童中,脑瘫病例数量呈稳步下降趋势。出生体重为1001 - 1500克的极低出生体重儿(VLBWI)比体重小于或等于1000克的超低出生体重儿(ELBWI)受脑瘫影响更严重。统计分析显示,神经运动发育与围产期以下因素之间存在显著相关性:分娩类型、性别、需要辅助通气的呼吸窘迫、酸中毒、超声检查、孕40周时的神经系统检查。