Merkul'eva N S, Mikhalkin A A, Nikitina N I, Makarov F N
Morfologiia. 2011;140(6):24-31.
Development of axonal connections between cat primary visual area 17 and visual motion processing center was studied to investigate cortico-cortical connection plasticity in ontogenesis as affected by an experimental modification of visual environment (flickering light stimulation). By using a retrograde axonal labeling by horseradish peroxidase, a distribution of initial neurons in area 17 that send afferent projections to PMLS (posterior medial part of lateral suprasylvian sulcus) was analyzed. Sixteen 5-week-old and 12-14-week-old kittens, than were reared in normal visual environment or were subjected to a flickering light of 15 Hz frequency, were examined. It was shown that session stimulation by flickering light led to an impairment of normal development of regular organization of the connections between these visual areas including the decrease of labeled surface area and labeled initial neuron density in area 17. The data obtained elucidate the structural bases of cortical mechanisms that underlie motion processing disturbances in kittens stimulated by a flickering light.
为了研究视觉环境的实验性改变（闪烁光刺激）对个体发育过程中皮质-皮质连接可塑性的影响，研究了猫的初级视觉区17与视觉运动处理中心之间轴突连接的发育情况。通过使用辣根过氧化物酶进行逆行轴突标记，分析了向PMLS（外侧上薛氏沟后内侧部分）发送传入投射的17区起始神经元的分布。对16只5周龄和12 - 14周龄的小猫进行了检查，这些小猫分别饲养在正常视觉环境中或接受15Hz频率的闪烁光照射。结果表明，闪烁光的阶段性刺激导致这些视觉区域之间连接的正常规则组织发育受损，包括17区标记表面积和标记起始神经元密度的降低。所获得的数据阐明了受闪烁光刺激的小猫运动处理障碍背后的皮质机制的结构基础。
