Department of Internal Medicine I, Endocrine and Diabetes Unit, University of Wuerzburg, Wuerzburg, Germany.
Clin Endocrinol (Oxf). 2013 Mar;78(3):385-90. doi: 10.1111/j.1365-2265.2012.04409.x.
To retrospectively analyse the effectiveness of bariatric surgery for hypothalamic obesity in patients with craniopharyngioma (CP).
Patients who developed morbid obesity after surgery for CP and who underwent laparoscopic gastric banding (LAGB), laparoscopic sleeve gastrectomy or gastric bypass were included (n = 9). Patients with common obesity who underwent bariatric surgery served as controls (LAGB n = 40, sleeve gastrectomy n = 49 and gastric bypass n = 54).
CP was diagnosed during childhood or adolescence [median (range) 10 (1-21) years] and age at bariatric surgery was 17 [12-30] years. Six patients underwent gastric banding [median follow-up 5.5 years (range 1-9)], 4 had a sleeve gastrectomy [median follow-up 2 (0.4-4) years] and two patients had gastric bypass surgery (median follow-up 3 years). Three patients had more than one type of bariatric surgery. Different from controls, no weight loss was observed after LAGB or sleeve gastrectomy. The two patients who had gastric bypass surgery lost body weight comparable with controls.
With LAGB and sleeve gastrectomy, no significant loss of body weight was achieved in young adult patients with craniopharyngioma-associated morbid obesity.
回顾性分析颅咽管瘤（CP）术后发生肥胖症患者行减重手术的疗效。
纳入因 CP 术后发生病态肥胖且行腹腔镜胃束带术（LAGB）、腹腔镜袖状胃切除术或胃旁路术的患者（n=9）。将因普通肥胖行减重手术的患者作为对照组（LAGB n=40、袖状胃切除术 n=49 和胃旁路术 n=54）。
CP 于儿童或青少年期确诊[中位数（范围）10（1-21）岁]，减重手术年龄为 17[12-30]岁。6 例行胃束带术[中位数随访 5.5 年（范围 1-9）]，4 例行袖状胃切除术[中位数随访 2（0.4-4）年]，2 例行胃旁路术。3 例患者接受了不止一种减重手术。与对照组不同，LAGB 或袖状胃切除术术后体重均无明显减轻。行胃旁路术的 2 例患者体重减轻与对照组相当。
在颅咽管瘤相关病态肥胖的年轻成年患者中，行 LAGB 和袖状胃切除术不能显著减轻体重。
