Department of Dermatology, University of Berlin, Skin Cancer Center Charite, HTCC, Chariteplatz 1, 10117 Berlin, Germany.
Expert Opin Biol Ther. 2012 Jun;12(6):783-93. doi: 10.1517/14712598.2012.676036. Epub 2012 Apr 16.
Sinecatechins is a standardized extract of green tea leaves, containing a mixture of catechin compounds. The 15% ointment has been approved for the topical treatment of condylomata acuminata (CA), caused by particular human papillomaviruses (HPV), mainly HPV types 6 and 11.
To update the use of sinecatechins for treatment of CA and to describe possible mechanisms involved in the mode of action.
The clearance rate of wart lesions after treatment with sinecatechins is similar to other topically applied drugs, like imiquimod and podophyllotoxin, but recurrences are seen less frequently after treatment with sinecatechins. The molecular mode of action underlying the clinical efficacy has yet not been characterized, but the following properties are likely to be involved in the regression of genital warts: activation of cellular immune reactions, induction of cell cycle arrest and apoptosis, inhibition of HPV gene expression.
Sinecatechins is a safe and effective treatment option for CA. Due to the variety of molecular activities of catechins the product has great potential for application to other viral and tumor lesions in the future.
绿茶儿茶素是一种标准化的绿茶提取物，含有儿茶素混合物。15%的软膏已被批准用于局部治疗由特定人乳头瘤病毒（HPV）引起的尖锐湿疣（CA），主要是 HPV 类型 6 和 11。
更新儿茶素在 CA 治疗中的应用，并描述作用机制中涉及的可能机制。
儿茶素治疗后疣病变的清除率与其他局部应用药物（如咪喹莫特和鬼臼毒素）相似，但儿茶素治疗后复发频率较低。尚未确定其临床疗效的分子作用模式，但以下特性可能与生殖器疣的消退有关：细胞免疫反应的激活、细胞周期停滞和细胞凋亡的诱导、HPV 基因表达的抑制。
儿茶素是治疗 CA 的安全有效的选择。由于儿茶素的多种分子活性，该产品在未来很有可能应用于其他病毒和肿瘤病变。
