de Man R A, Schalm S W, Sprecher-Goldberger S, Stibbe J, van de Ende M E, Schrijnemakers P, Rothbarth P H
Department of Internal Medicine & Hepatogastroenterology, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Neth J Med. 1990 Oct;37(3-4):141-4.
In order to find suitable markers for selection and monitoring of antiviral therapy in asymptomatic HIV-infected patients, we evaluated 18 anti-HIV positive individuals at three monthly intervals by HIV culture, HIV antigen, and core (p24) antibody testing as well as by measurement of lymphocyte subsets. Consistent results were obtained with HIV antigen, p24 antibody testing and T4 cell enumeration, whereas results of virus detection were variable. Therefore cumbersome and expensive virus culture is not of use in selecting patients for antiviral therapy. On the basis of our results and recent literature we currently propose using absence of p24 antibodies, presence of HIV antigen and low or falling T4 cells as eligibility criteria for antiviral therapy in asymptomatic infected individuals.
为了寻找适用于无症状HIV感染患者抗病毒治疗选择和监测的标志物，我们对18名抗HIV阳性个体每隔三个月进行一次评估，评估项目包括HIV培养、HIV抗原、核心（p24）抗体检测以及淋巴细胞亚群测定。HIV抗原、p24抗体检测和T4细胞计数结果一致，而病毒检测结果则不一致。因此，繁琐且昂贵的病毒培养对于选择抗病毒治疗患者并无用处。根据我们的研究结果和近期文献，我们目前建议将无p24抗体、存在HIV抗原以及T4细胞数量低或下降作为无症状感染个体抗病毒治疗的入选标准。
