Cangelosi C, Giardina R A, Pecoraro G, Marcianò R, Vitale M G, Gullotti A, Caronia F, Spanò C
Ann Ig. 1989 Jan-Apr;1(1-2):45-50.
The acquired immunodeficiency syndrome (AIDS) is caused by the HIV infection in people with an already impaired immunological system. The seroprevalence follow-up of different markers of HIV should seem to suggest to predict the course of the disease as well as the T4/T8 ratio did. We examined 111 at risk anti-HIV positive people according to these parameters in comparison with their clinical situation. Serum samples from these subjects were examined by means of the ELISA method for anti-ENV/CORE antibodies and HIV antigen, followed by a Western Blot confirmation. The T4/T8 ratio was controlled and measured by means of monoclonal immunofluorescent antibody test. Sixty six out of eighty three (79.5%) symptomatic patients showed a less than 1.0 T4/T8 ratio in comparison with 15/28 (53.6%) asymptomatic people (p less than 0.01) while no difference was seen in the same patients according to the presence or not of anti-core antibodies. In some patients it was possible to observe a positive trend in the T4/T8 ratio.
获得性免疫缺陷综合征（艾滋病）是由免疫系统已经受损的人感染艾滋病毒引起的。对艾滋病毒不同标志物的血清流行率进行随访，似乎应该能像T4/T8比值那样预测疾病进程。我们根据这些参数检查了111名有感染艾滋病毒风险的抗艾滋病毒阳性者，并将其与他们的临床情况进行比较。通过酶联免疫吸附测定法检测这些受试者血清样本中的抗包膜/核心抗体和艾滋病毒抗原，随后进行蛋白质印迹法确认。通过单克隆免疫荧光抗体试验控制和测量T4/T8比值。83名有症状患者中有66名（79.5%）的T4/T8比值低于1.0，而28名无症状者中有15名（53.6%）的T4/T8比值低于1.0（p<0.01），而根据是否存在抗核心抗体，同一批患者之间未观察到差异。在一些患者中，可以观察到T4/T8比值呈上升趋势。
