Department of Nutritional Sciences and Toxicology, University of California at Berkeley, USA.
Reprod Toxicol. 2012 Aug;34(1):125-32. doi: 10.1016/j.reprotox.2012.03.010. Epub 2012 Apr 14.
Universal prenatal daily supplementation with iron (60-120mg iron) plus folic acid (0.4mg), as recommended by INACG/WHO/UNICEF, prevents anemia where iron deficiency is prevalent but may be excessive for non-anemic women. Weekly supplementation with 120mg iron plus various amounts of folic acid similarly prevents significant anemia.
Determine, in non-anemic pregnant women, if oxidative stress is produced by recommended daily or weekly supplementation schemes.
100 non-anemic pregnant women, 30% iron-deficient at week 20, were randomly supplemented daily followed by weekly, each for 8 weeks, or in reversed order.
With daily supplementation thio-barbituric-acid-reacting-substances (TBARS) increased significantly and high serum ferritin, iron, and excessively elevated hemoglobin occurred near term. During weekly supplementation significant anemia and high iron parameters were prevented, and elevated TBARS declined.
In non-anemic pregnant women both schemes prevented significant anemia. Oxidative stress occurred only during daily supplementation periods. Weekly supplementation appears safer.
在非贫血孕妇中确定推荐的每日或每周补充方案是否会产生氧化应激。
100 名非贫血孕妇，20 周时有 30%缺铁，随机每日补充，然后每周补充，各持续 8 周，或按相反顺序补充。
每日补充时，硫代巴比妥酸反应物质（TBARS）显著增加，且接近足月时血清铁蛋白、铁和血红蛋白过高。每周补充时，可预防显著贫血和高铁参数，并降低升高的 TBARS。
在非贫血孕妇中，两种方案都能预防显著贫血。只有在每日补充期间才会发生氧化应激。每周补充似乎更安全。
